Patents by Inventor Phil G. Campbell

Phil G. Campbell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11540921
    Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: January 3, 2023
    Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Liliana Camison Bravo, Phil G. Campbell, Toygun Cetinkaya, O. Burak Ozdoganlar, Lucas A. Dvoracek, Jesse A. Goldstein
  • Publication number: 20220354990
    Abstract: A method of immobilizing extracellular vesicles in an extracellular matrix material provides for improved extracellular vesicle retention in vitro and in vivo. Extracellular matrix materials, such as collagen, are functionalized with chemicals that are complimentary to ligands disposed on the surface of the extracellular vesicle. In one example embodiment, collagen is functionalized with dibenzocyclooctyne and the extracellular vesicle is functionalized with an azide tag. The extracellular vesicle is immobilized within the collagen through a click reaction involving the dibenzocyclooctyne and the azide tag.
    Type: Application
    Filed: May 10, 2022
    Publication date: November 10, 2022
    Applicant: Carnegie Mellon University
    Inventors: Xi Ren, Phil G. Campbell, Yunhui Xing, Saigopalakrishna Saileelaprasa Yerneni
  • Publication number: 20220145291
    Abstract: Provided herein are tethered extracellular vesicles and methods of making tethered extracellular vesicles.
    Type: Application
    Filed: February 14, 2020
    Publication date: May 12, 2022
    Inventors: Subha Ranjan Das, Phil G. Campbell, Krzysztof Matyjaszewski, Sushil Lathwal, Saigopalakrishna Saileelaprasad Yernei
  • Publication number: 20210307912
    Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.
    Type: Application
    Filed: April 1, 2021
    Publication date: October 7, 2021
    Applicants: CARNEGIE MELLON UNIVERSITY, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Liliana Camison Bravo, Phil G. Campbell, Toygun Cetinkaya, O. Burak Ozdoganlar, Lucas A. Dvoracek, Jesse A. Goldstein
  • Publication number: 20210187262
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 24, 2021
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Patent number: 10894151
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: January 19, 2021
    Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Publication number: 20180119077
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 3, 2018
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Patent number: 9364503
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: June 14, 2016
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20150165093
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 18, 2015
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8911789
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: December 16, 2014
    Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute, Carmell Therapeutics Corporation
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529960
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carnell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529958
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529961
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529959
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529956
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: September 10, 2013
    Assignees: Carnell Therapeutics Corporation, Carnegie Mellon University, Allegheny-Singer Research Institute
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8293530
    Abstract: A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: October 23, 2012
    Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute
    Inventors: James E. Burgess, Phil G. Campbell, Lee E. Weiss, Jason Smith
  • Publication number: 20120177694
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: July 6, 2011
    Publication date: July 12, 2012
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20120003279
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 5, 2012
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20120003193
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 5, 2012
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20120003324
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 5, 2012
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith