Patent number: 9833423
Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
Type:
Grant
Filed:
April 14, 2016
Date of Patent:
December 5, 2017
Assignees:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D
Inventors:
Young Sik Jung, Chong Kgo Lee, Ihl Young Choi, Hae Soo Kim, Phil Ho Kim, Soo Bong Han, Johan Neyts, Hendrik Jan Thibaut
Publication number: 20160272564
Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hapatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
Type:
Application
Filed:
April 14, 2016
Publication date:
September 22, 2016
Inventors:
Young Sik JUNG, Chong Kgo LEE, Ihl Young CHOI, Hae Soo KIM, Phil Ho KIM, Soo Bong HAN, Johan NEYTS, Hendrik Jan Thibaut