Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to natural killer (NK) cells. The invention also includes multimeric binding complexes comprising at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands or said multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by natural killer (NK) cells, such as inflammatory disorders, autoimmune disease and cancer.

Abstract: A mechanical link includes a carrier for supporting a conductor within a mechanical link. The mechanical link may include a first arm and a second arm, the second arm being arranged for movement with respect to the first arm, and a flexible helical carrier for supporting a conductor, wherein the flexible helical carrier is received within the first and second arms. The carrier may be, or may include a generally helical member of a flexible material, the generally helical member comprising a continuous support portion having on both sides thereof upstanding wall portions.

Abstract: A mechanical link (100, FIG. 5), the mechanical link comprising a first arm (120), a second arm (140) and an interconnection member (160), wherein: the first arm is rotatable about a first axis of the interconnection member; the second arm is rotatable about a second axis of the interconnection member, the second axis being orthogonal to the first axis; and wherein: a flexible member (400) extends along the first and second arms and is adapted to accommodate rotation of the arms about the first and second axes, the flexible member having a single coiled portion (440) which is received within the interconnection member such that the coiled portion can coil and uncoil to accommodate rotation of the first arm, wherein the coiled portion is further configured to twist about an axis of the flexible member to accommodate rotation of the second arm.

Abstract: A mechanical link includes a carrier for supporting a conductor within a mechanical link. The mechanical link may include a first arm and a second arm, the second arm being arranged for movement with respect to the first arm, and a flexible helical carrier for supporting a conductor, wherein the flexible helical carrier is received within the first and second arms. The carrier may be, or may include a generally helical member of a flexible material, the generally helical member comprising a continuous support portion having on both sides thereof upstanding wall portions.

Abstract: A mechanical link (100, FIG. 5), the mechanical link comprising a first arm (120), a second arm (140) and an interconnection member (160), wherein: the first arm is rotatable about a first axis of the interconnection member; the second arm is rotatable about a second axis of the interconnection member, the second axis being orthogonal to the first axis; and wherein: a flexible member (400) extends along the first and second arms and is adapted to accommodate rotation of the arms about the first and second axes, the flexible member having a single coiled portion (440) which is received within the interconnection member such that the coiled portion can coil and uncoil to accommodate rotation of the first arm, wherein the coiled portion is further configured to twist about an axis of the flexible member to accommodate rotation of the second arm.