Abstract: The present invention discloses a method and apparatus for molding a fibrous molded article. An aqueous slurry that contains an amount of water and a plurality of fibers is added to the molding apparatus. First and second molding screens are positioned on a first pressing unit and a second pressing unit, respectively, and include a plurality of openings. The first and second molding screens can include secondary relief features. A pressing chamber sleeve slidably engages with the first pressing unit and the second pressing unit to ensure proper alignment during molding operation. The first and second molding screens at least partially form a void that is intended to receive an amount of the aqueous slurry. The apparatus includes a heat and pressure source that removes at least some of the water from the aqueous slurry and bonds the fibers to one another resulting in the fibrous molded article.

Abstract: The present invention is a method for forming a fibrous molded article that includes providing a aqueous slurry containing a plurality of fibers, providing the slurry into a dehydration chamber to remove at least some of the amount of water from the slurry to achieve an intermediate form, removing the fibrous intermediate form from the dehydration chamber and placing the fibrous intermediate form in a press having a first mold portion and a second mold portion wherein at least one of the first or second mold portions includes a contour, applying at least one of heat and pressure to the press such that at least fiber to fiber bonding or chemical cross-linking of fibers occurs, and removing the three-dimensional solid fibrous molded part from the press.

Abstract: The present invention discloses a molded article having a surface feature created by a light reactive agent interacting with light from a light source, and a method for making the same. The article is molded from a slurry comprised of an aqueous solution that includes a plurality of fibers and a light reactive agent. The slurry is molded into a three-dimensional solid fibrous molded part. The solid fibrous molded part is exposed to a light source such that the light reacts with the light reactive agent to create at least one surface feature. The surface feature can be, for example, a texture or a color change.

Abstract: The present invention is directed to a method of making at least a portion of a garment that includes at least one three-dimensional contour. The disclosed method includes providing a fiber and solvent mixture that includes fibers and a solvent capable to causing a plurality of covalent bonds to be created between the fibers. In many embodiments, the plurality of covalent bonds form when a catalyst, such as heat, is provided to the fiber and solvent mixture. The process can be performed using, for example, either a 3D printer or mold form. The fibers used can be natural, synthetic, or a blend of natural and/or synthetic fibers. The solvent preferably includes ionic salts in water.

Abstract: Methods and apparatus, including computer program products, are provided for remote monitoring. In some example implementations, there is provided a method. The method may include receiving, at a remote monitor, a notification message representative of an event detected, by a server, from analyte sensor data obtained from a receiver monitoring an analyte state of a host; presenting, at the remote monitor, the notification message to activate the remote monitor, wherein the remote monitor is configured by the server to receive the notification message to augment the receiver monitoring of the analyte state of the host; accessing, by the remote monitor, the server, in response to the presenting of the notification message; and receiving, in response to the accessing, information including at least the analyte sensor data. Related systems, methods, and articles of manufacture are also disclosed.

Abstract: A system including a magnetic coil and a coil driver is described. The magnetic coil has a parasitic capacitance. The coil driver is coupled with the magnetic coil. The coil driver includes a pulse generator and a switching module coupled with the pulse generator. The pulse generator provides a pulse train. The switching module receives the pulse train and provides a switched driving signal to the magnetic coil. The switched driving signal has a frequency not less than a parasitic capacitance frequency.

Abstract: The present invention is directed to a method of making at least a portion of a garment that includes at least one three-dimensional contour. The disclosed method includes providing a fiber and solvent mixture that includes fibers and a solvent capable to causing a plurality of covalent bonds to be created between the fibers. In many embodiments, the plurality of covalent bonds form when a catalyst, such as heat, is provided to the fiber and solvent mixture. The process can be performed using, for example, either a 3D printer or mold form. The fibers used can be natural, synthetic, or a blend of natural and/or synthetic fibers. The solvent preferably includes ionic salts in water.

Abstract: An electronic wagering system may include a wager selection station, a server, and a software application executed by a mobile communication device. At least one processor of the wager selection station may accept user input specifying parameters of an event on which to place a wager, generate a unique reference from which the specified event parameters are derivable, encode the unique reference in a machine-readable optical code, and display the generated optical code. The software application may operate the user's mobile communication device to scan the displayed optical code, retrieve the unique reference by decoding the scanned optical code, transmit the unique reference to the server for deriving the specified event parameters from the unique reference at the server, receive user input to place a wager on the event with the specified parameters, and transmit a request to the server to place the wager on behalf of the user.

Abstract: The disclosure relates to transferred learning from a first language (e.g., a source language for which a semantic parser has been defined) to a second language (e.g., a target language for which a semantic parser has not been defined). A system may use knowledge from a trained model in one language to model another language. For example, the system may transfer knowledge of a semantic parser from a first (e.g., source) language to a second (e.g., target) language. Such transfer of knowledge may occur and be useful when the first language has sufficient training data but the second language has insufficient training data. The foregoing transfer of knowledge may extend the semantic parser for multiple languages (e.g., the first language and the second language).

Abstract: The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.

Abstract: The disclosure relates to transferred learning from a first language (e.g., a source language for which a semantic parser has been defined) to a second language (e.g., a target language for which a semantic parser has not been defined). A system may use knowledge from a trained model in one language to model another language. For example, the system may transfer knowledge of a semantic parser from a first (e.g., source) language to a second (e.g., target) language. Such transfer of knowledge may occur and be useful when the first language has sufficient training data but the second language has insufficient training data. The foregoing transfer of knowledge may extend the semantic parser for multiple languages (e.g., the first language and the second language).

Abstract: The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.

Abstract: The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.

Abstract: An electronic wagering system may include a wager selection station, a server, and a software application executed by a mobile communication device. At least one processor of the wager selection station may accept user input specifying parameters of an event on which to place a wager, generate a unique reference from which the specified event parameters are derivable, encode the unique reference in a machine-readable optical code, and display the generated optical code. The software application may operate the user's mobile communication device to scan the displayed optical code, retrieve the unique reference by decoding the scanned optical code, transmit the unique reference to the server for deriving the specified event parameters from the unique reference at the server, receive user input to place a wager on the event with the specified parameters, and transmit a request to the server to place the wager on behalf of the user.

Abstract: The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.

Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

Abstract: The invention relates to kinase inhibitors of the formula (I) in which —R1 to R4?H; ether or polyether, amino; NO2; NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; —R5=—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; N(R9,R10); —R5??H or a C1-C12 alkyl, —R6?H; R; (R or R?)3—Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R7 and R8?H, C1-C12 alkyl; —R9 and R10?H, R (or R?) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.

Abstract: The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.

Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTlF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.