Abstract: A needle insertion system is disclosed that includes a moveable hollow needle having a distal tip configured to be transdermally inserted into a vertebrate subject at an insertion-target region; at least one sensor operable to detect skin structure at a position in proximity to the distal tip of the moveable needle in the insertion-target region; and control circuitry operably coupled to the at least one sensor and configured to receive information therefrom indicating the skin structure at the insertion-target region in proximity to the distal tip, and the control circuitry configured to output moveable needle targeting instructions to control movement of the moveable needle into the skin in response to one or more signals from the at least one sensor detecting the skin structure in proximity to the distal tip. A method for inserting a movable needle of a needle insertion system into a vertebrate subject is disclosed.

Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Abstract: A method of customizing hardware by an end user for a mobile phone is provided. The method includes receiving from an end-user a selection of a mobile phone shell from a set of mobile phone shells, sending to the end-user a subset of interchangeable hardware components having different functions, and receiving from the end-user a selection of at least one hardware component from the subset of interchangeable hardware components. The subset of interchangeable hardware components is generated based on a compatibility between the selected mobile phone shell and the set of available interchangeable hardware components.

Abstract: A computerized method of customizing hardware for a mobile phone is provided. The method includes receiving shell selection information from a user input device, identifying a set of hardware components, the set of hardware components generated based on a compatibility between the hardware components and the shell selection information, and outputting the identified set of compatible hardware components.

Abstract: In some embodiments, a portable cooling unit for use with a storage container includes: a desiccant unit including at least one exterior wall defining an interior desiccant region, wherein the interior desiccant region is sealed from gas transfer between the interior desiccant region and a region external to the cooling unit; an evaporative cooling unit including at least one exterior wall defining an interior evaporative region, wherein the interior evaporative region is sealed from gas transfer between the interior evaporative region and the region external to the cooling unit; a vapor conduit including a first and a second end, the vapor conduit attached to the desiccant unit at the first end, the vapor conduit attached to the evaporative cooling unit at the second end, the vapor conduit forming a passageway between the interior desiccant region and the interior evaporative region; and a vapor control unit attached to the vapor conduit.

Abstract: A germination facility includes a seedling growing system configured to grow a plurality of seedlings; and a seedling sorting device configured to receive spatially variable planting data regarding a planting area for planting the seedlings; receive seedling data regarding the plurality of seedlings; and arrange the plurality of seedlings in a planting container based on the seedling data and on the planting data.

Abstract: In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.

Abstract: A mobile phone includes a shell and a hardware component coupled to the shell, wherein the hardware component is selected from a set of interchangeable components having substantially the same size but different functions.

Abstract: In some embodiments, a system for responsive release of a medicament in an artificial joint region includes: an implantable sensor unit including at least one sensor, the implantable sensor unit configured to be implanted in an artificial joint region; a responsive release control unit including an electronic controller and memory, the responsive release control unit configured to receive signals from the implantable sensor unit and to send signals to an implantable medicament release unit; and the implantable medicament release unit, including a reservoir and a controllable release unit attached to the reservoir, the controllable release unit configured to provide access to the reservoir in response to signals from the responsive release control unit, the implantable medicament release unit configured to be implanted in the artificial joint region.

Abstract: In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

Abstract: A method of customizing hardware by an end user for a mobile phone is provided. The method includes receiving from an end-user a selection of a mobile phone shell from a set of mobile phone shells, sending to the end-user a subset of interchangeable hardware components having different functions, and receiving from the end-user a selection of at least one hardware component from the subset of interchangeable hardware components. The subset of interchangeable hardware components is generated based on a compatibility between the selected mobile phone shell and the set of available interchangeable hardware components.

Abstract: Methods, systems, and devices are described for calculating a push pressure for a pharmaceutical vial with a syringe, the method including accepting data regarding at least one parameter of the pharmaceutical vial, at least one parameter of a vial cap with a seal, at least one parameter of the syringe, and a single dose volume of a liquid pharmaceutical; calculating a volume of headspace over the liquid pharmaceutical with a computing device; calculating an ejection pressure based on the single dose volume of the liquid pharmaceutical and the volume of headspace; calculating a motive pressure based on a static force and a cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user. The method further includes calculating a molar amount of inert gas needed in the pharmaceutical vial to generate the calculated push pressure.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: A computerized method of customizing hardware for a mobile phone is provided. The method includes receiving shell selection information from a user input device, identifying a set of hardware components, the set of hardware components generated based on a compatibility between the hardware components and the shell selection information, and outputting the identified set of compatible hardware components.

Abstract: A computerized method of customizing hardware for a mobile phone is provided. The method includes receiving shell selection information from a user input device, identifying a set of hardware components, the set of hardware components generated based on a compatibility between the hardware components and the shell selection information, and outputting the identified set of compatible hardware components.

Abstract: A computerized method of customizing hardware for a mobile phone is provided. The method includes receiving shell selection information from a user input device, identifying a set of hardware components, the set of hardware components generated based on a compatibility between the hardware components and the shell selection information, and outputting the identified set of compatible hardware components.

Abstract: A mobile phone includes a shell and a hardware component coupled to the shell, wherein the hardware component is selected from a set of interchangeable components having substantially the same size but different functions.

Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Abstract: A computerized method of customizing hardware for a mobile phone is provided. The method includes receiving shell selection information from a user input device, identifying a set of hardware components, the set of hardware components generated based on a compatibility between the hardware components and the shell selection information, and outputting the identified set of compatible hardware components.

Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.