Abstract: The invention relates to amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract: The invention relates to pyridone amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 targets polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.

Abstract: A transparent electric-arc resistant composition is produced by preparing crystalline tungsten bronze nanoparticles and homogenously dispersing the nanoparticles in a transparent plastic matrix. The crystalline tungsten bronze nanoparticles are prepared by homogeneously mixing an aqueous solution of soluble tungsten and cesium salts and then drying the solution. The dried solution is then heated in a reducing gas or inert gas atmosphere to form crystalline tungsten bronze nanoparticles. Thereafter, a dispersion agent is added and the nanoparticles are dispersed in a liquid solvent medium by wet milling to form a dispersion mixture. The dispersion mixture is then mixed with polymer pellets to form a polymer mixture, and the polymer mixture is then extruded to yield polymer pellets containing highly homogeneously dispersed inorganic nanoparticles. During or after dispersion, additional particles, dyes, heat stabilizers or UV absorbers, may be added. A lens or shield is then molded from the polymer pellets.

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract: The invention relates to amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract: The invention relates to pyridone amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: A spin-on filter cartridge includes a housing, a filter element operably oriented in the housing, a baffle plate, and a seal arrangement. The baffle plate is operably oriented over the housing open end. The baffle plate defines a central flow aperture. The baffle plate defines a continuous groove immediately adjacent to and circumscribing the central flow aperture. The seal arrangement is secured to the baffle plate spaced from and circumscribing the continuous groove. In another aspect, a filter assembly includes a spin-on filter cartridge as characterized above and a filter head. The spin-on filter cartridge is removably mountable on the filter head. The filter head includes a central spud defining outer threads. An O-ring seal member or a gasket seal member is operably oriented around the central spud.

Abstract: A method for dynamic electrical testing of head gimbal assemblies may include initiating an automated continuous process that includes selecting an unmounted head gimbal assembly; aligning the unmounted head gimbal assembly; loading the unmounted head gimbal assembly to a disc; and testing the unmounted head gimbal assembly.

Abstract: A method for dynamic electrical testing of head gimbal assemblies may include initiating an automated continuous process that includes selecting an unmounted head gimbal assembly; aligning the unmounted head gimbal assembly; loading the unmounted head gimbal assembly to a disc; and testing the unmounted head gimbal assembly.

Abstract: A method for dynamic electrical testing of head gimbal assemblies may include initiating an automated continuous process that includes selecting an unmounted head gimbal assembly; aligning the unmounted head gimbal assembly; loading the unmounted head gimbal assembly to a disc; and testing the unmounted head gimbal assembly.

Abstract: A method for dynamic electrical testing of head gimbal assemblies may include initiating an automated continuous process that includes selecting an unmounted head gimbal assembly; aligning the unmounted head gimbal assembly; loading the unmounted head gimbal assembly to a disc; and testing the unmounted head gimbal assembly.

Abstract: A method for dynamic electrical testing of head gimbal assemblies may include initiating an automated continuous process that includes selecting an unmounted head gimbal assembly; aligning the unmounted head gimbal assembly; loading the unmounted head gimbal assembly to a disc; and testing the unmounted head gimbal assembly.

Abstract: The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver genes encoding human immunodeficiency virus entry inhibitors to target cells in mammals.

Abstract: A filter element includes a first, outer tubular construction of filter media defining a first open filter interior; a second, inner tuber construction of filter media defining a second open filter interior; the second construction of filter media being located within the first open filter interior and being radially spaced from the first construction of filter media; and the second open filter interior defines an unfiltered fluid channel. A plastic inner liner is within the first open filter interior to support the first construction of filter media. A plastic outer liner is within the first open filter interior to support the second construction of filter media. A filtered fluid channel is defined between the inner liner and the outer liner. A brace arrangement is between the first and second tubular constructions. The brace arrangement can include a spring, a plurality of gussets, or a solid spacer.

Abstract: Disclosed is a system and method for channel decoding speech frames in a receiver capable of multiple (M) codec modes, wherein channel encoded speech frames include an inband bit portion and a speech portion. An inband bit decoder decodes the inband bit portion (700) of a received frame to obtain confidence levels associated with each of the M codec modes. Using these confidence levels, the codec modes are ordered from most to least likely. The speech frame is then decoded by a channel decoder using the most likely codec mode (704). A frame determination check (720) is performed to determine the quality of the decoded speech frame. If the decoded speech frame is determined to be of poor quality, then the channel decoding process is repeated using the next most likely codec mode (736) corresponding to the next highest inband bit decoding confidence level. This process is repeated until a good speech frame is decoded or some exit criteria is reached.

Abstract: A system provides a digital multi-bit connection between two or more graphics adapters. Each graphics adapter is manufactured as a printed circuit board including a finger-type edge connector. When two or more graphics adapters are installed in a system the edge connectors of each graphics adapter may be coupled to each other via a connection device that provides a portion of the digital multi-bit connection. The remainder of the digital multi-bit connection is provided by conductive traces coupling each finger of the edge connector to a graphics processing unit that is affixed to the graphics adapter. The connection device may be installed by an end-user as each additional graphics adapter is installed in the system.