Abstract: The present invention relates to compounds (e.g. ISVDs, polypeptides, polypeptide derivatives) capable of binding to Interleukin-6 (IL-6) and their use in the treatment of inflammatory diseases such as, e.g. cardiovascular disease (CVD).

Abstract: The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous—as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration.

Abstract: The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous—as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration.

Abstract: The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

Abstract: The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

Abstract: The invention relates to pharmaceutical compositions comprising a PCSK9 inhibitor, such as an EGF(A) peptide, and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

Abstract: The invention relates to pharmaceutical compositions comprising a GLP-1 agonist, an SLGT2 inhibitor, a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid, and a hydrotrope. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

Abstract: The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

Abstract: A method can be used to perform an operation on a system that includes an assembly and a vessel that includes a wall and a thermal shield. The method can include breaking a thermal connection between the assembly and the thermal shield, separating the assembly and a surface within the vessel from each other, or any combination thereof. The method can also include changing a pressure with the vessel to be closer to atmospheric pressure, heating the assembly, or any combination thereof. In one embodiment, the method can be performed while keeping a cryogenic region substantially sealed, keeping a superconducting magnet energized, or a combination thereof. In a particular embodiment, the method can be used when servicing the assembly, such as a cryocooler.

Abstract: A seat, a chair, or a combination thereof can be part of or used in conjunction with an MRI system. The seat can be designed to allow for an MRI analysis without requiring insertion of a probe into a cavity of a patient. In one embodiment, the seat and chair can be adapted for use with a cylindrical-type MRI system. The seat and chair may be used with another type of MRI system, such as an open MRI system. The pelvic region or adjacent portion of a patient can be analyzed without the patient having to lie flat.

Abstract: A cylindrical MRI system can be configured such that a patient does not have to be in a lying position during analysis. In a particular embodiment, the patient can sit during analysis. The cylindrical MRI system can be oriented such that a central axis is not parallel to the floor, and in one embodiment, is substantially perpendicular to the floor. In one embodiment, the cylindrical MRI system can be configured to allow an object to contact the patient when the patient is within the analyzing region, even when the primary magnet is at field. In another aspect, an MRI system can include a primary magnet and a gradient coil with different types of shapes. In still another aspect, an MRI system can include a gradient coil that includes a combination of portions having different shapes.

Abstract: A switch can be used in conjunction with a superconducting current path to provide a more reliable circuit and system. The switch can be connected in parallel with a portion of the superconducting current path. In one embodiment, the switch may be connected in parallel with an entire superconducting element, such as a persistent current switch, a superconducting coil, or the like, or may be connected in parallel across only a portion of a superconducting element. A method of using the system is also disclosed.

Abstract: A method can be used to perform an operation on a system that includes an assembly and a vessel that includes a wall and a thermal shield. The method can include breaking a thermal connection between the assembly and the thermal shield, separating the assembly and a surface within the vessel from each other, or any combination thereof. The method can also include changing a pressure with the vessel to be closer to atmospheric pressure, heating the assembly, or any combination thereof. In one embodiment, the method can be performed while keeping a cryogenic region substantially sealed, keeping a superconducting magnet energized, or a combination thereof. In a particular embodiment, the method can be used when servicing the assembly, such as a cryocooler.

Abstract: A superconducting magnet is accessible for ramping within a cryostat by inserting flexible current leads through openings in the cryostat and pushing and twisting these leads inward until connections are made with electrical contacts provided on the superconducting magnet. For each current lead, a permanently installed channel guides the lead as it is pushed through the external opening and extends to make contact with the magnet terminal. The guide channel extends outside of the cryostat and includes an internal or external bend, whereby the overhead space required for the cryostat/magnet assembly may be reduced. After ramping, the leads are withdrawn.

Abstract: A MRI cryostat, which contains a superconducting magnet operating in a bath of liquid helium, reduces the boil-off rate of helium by intercepting most of the heat in-leakage by means of a throttle cycle (TC) refrigerator operating at a low side temperature of about 90K. The main heat exchanger for the throttle cycle refrigerator is located within or immediately adjacent to the cryostat housing and delivers cold liquid to a cold heat exchanger that is in thermal contact with an outer radiation shield, support struts, neck tube and electrical leads inside the cryostat. Heat is intercepted by the outer shield from essentially all paths between a 300K ambient and a 4K load temperature, which temperature results from liquid helium boil-off to atmosphere. A second, inner radiation shield at 35K is cooled by gaseous helium that boils from the liquid helium bath. There are no moving parts of the refrigeration system in the cryostat. Thus, vibration, noise and disturbance of the magnetic field are reduced.

Abstract: A superconducting magnetic element is provided wherein the terminals are bonded to the coil body and are independent of that coil body supporting structure. The technology employs a terminal structure with a supporting base member surrounding a conductor terminal end portion positioned on a surface of an impregnated coil body and integrally bonded thereto. The terminal structure in turn permits freedom in manufacturing to employ all useful strategies in accommodating physical properties of different materials.