Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A computer-readable recording medium including a program which is executed by a computer apparatus to provide a video game comprising a virtual game world presented to a player of the video game, and a plurality of characters in the virtual game world including a first character, and a second character controlled by the player, the program causing the computer apparatus to function as: a state indicator generating unit configured to generate a state indication, wherein the state indication is an indication of an emotional or physical state of the first character; and a coupling indicator generating unit configured to generate a coupling indication, wherein the coupling indication is an indication of a coupling occurring between the emotional or physical state of the first character and an emotional or physical state of the second character.

Abstract: An apparatus is described for supporting payloads at high elevations with respect to a planetary body. The apparatus comprises a bearing that encircles a portion of a planetary body. One ring of the bearing rotates, and a coupling mechanism transfers centripetal forces to another non-rotating ring. Lift stays connect the non-rotating ring to the planetary body; and contribute a force that is in equilibrium with the centripetal and gravitational forces. A preferred embodiment is constructed and tested in the ocean and then raised to altitude. Its coupling mechanism employs magnetic forces and its lift stays are interwoven, partially supported and stabilized aeronautically, and anchored to the planet. The apparatus's elevation is not supported by transferring forces to the surface through the inertia of precision-guided high velocity components, thus these components are not necessarily exposed to seismic activity, weather, or anomalous air traffic.

Abstract: Optimized-coverage selective laser ablation systems and methods may be utilized to prepare (ablate) a three-dimensional surface. Methods comprise receiving a 3D virtual model of the surface to be ablated, generating a preliminary ablation path, and optimizing the preliminary ablation path to produce an adapted ablation path. Methods may comprise ablating the surface according to the adapted ablation path. The preliminary ablation path may be based on scanning a laser sheet across a two-dimensional projection of the surface. The optimization may adjust one or more waypoints of the preliminary ablation path to achieve complete coverage of the surface at acceptable levels of ablation, with little to no ablation outside the surface, and with acceptable (e.g., at least locally minimal) time to ablate the surface.

Abstract: An example composition includes a cloth, which has on each side thereof, a first waterproofing agent, a barrier which inhibits or prevents environmental degradation, and an elastomeric barrier including a second waterproofing agent. Another example composition includes a cloth with a phenolic resin coating having, on each side thereof, a first waterproofing agent, a barrier which inhibits or prevents environmental degradation, and an elastomeric barrier including a second waterproofing agent.

Abstract: Optimized-coverage selective laser ablation systems and methods may be utilized to prepare (ablate) a three-dimensional surface. Methods comprise receiving a 3D virtual model of the surface to be ablated, generating a preliminary ablation path, and optimizing the preliminary ablation path to produce an adapted ablation path. Methods may comprise ablating the surface according to the adapted ablation path. The preliminary ablation path may be based on scanning a laser sheet across a two-dimensional projection of the surface. The optimization may adjust one or more waypoints of the preliminary ablation path to achieve complete coverage of the surface at acceptable levels of ablation, with little to no ablation outside the surface, and with acceptable (e.g., at least locally minimal) time to ablate the surface.

Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.

Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.

Abstract: An example composition includes a cloth, which has on each side thereof, a first waterproofing agent, a barrier which inhibits or prevents environmental degradation, and an elastomeric barrier including a second waterproofing agent. Another example composition includes a cloth with a phenolic resin coating having, on each side thereof, a first waterproofing agent, a barrier which inhibits or prevents environmental degradation, and an elastomeric barrier including a second waterproofing agent.

Abstract: An apparatus is described for supporting payloads at high elevations with respect to a planetary body. The apparatus comprises a bearing that encircles a portion of a planetary body. One ring of the bearing rotates and a coupling mechanism transfers centripetal forces to another non-rotating ring. Stays connect the non-rotating ring to the planetary body; and contribute a force that is in equilibrium with the centripetal and gravitational forces. A preferred embodiment is constructed and tested in the ocean encircling Antarctica and then raised to altitude. Its coupling mechanism employs magnetic forces and its stays are interwoven, partially supported and stabilized aeronautically, and anchored to southerly located towers that are affixed to bedrock. The machine's elevation is not supported by transferring forces to the surface through the inertia of precision-guided high velocity components, thus these components are not necessarily exposed to seismic activity, weather, or anomalous air traffic.

Abstract: A detector for detecting ionizing radiation comprises a scintillator 10 selected to emit light in response to incidence thereon of radiation to be detected, at least one detector 16 for detecting said emitted light, and at least one optical waveguide 12 for transmitting said emitted light to said detector 16. The optical waveguide typically comprises a flexible solid or hollow fiber that can be incorporated into a flexible mat or into a fiber-reinforced structure, so that the detector is integrated therewith.

Abstract: Systems and methods are disclosed for differential pressure meters having a constant beta edge boundary defined by fluid displacement members of the meter. In some embodiments, a differential pressure meter may have an interchangeable fluid displacement member, such that each fluid displacement member replaced in the meter maintains a constant beta edge boundary. In other embodiments, a family of differential pressure meters having permanent fluid displacement members may maintain a constant beta edge boundary for each meter of the family of differential pressure meters.

Abstract: An electrical power source including at least one hollow fiber incorporated in a material structure, wherein the at least one hollow fiber forms part of an electric circuit capable of storing or generating electrical power. In this way power sources may be provided as an integral part of a fiber composite structure or fabric.

Abstract: A process and apparatus for recycling municipal domestic waste comprises subjecting the waste to steam at 150° C.-200°. After steam treatment, the resultant material is separated into constituent parts and biomass and/or plastics subjected to further treatment. The further treatment preferably produces bioethanol from the biomass and diesel from the plastics. As an alternative, some or all of the biomass may be gasified in order to produce hydrogen which may, in turn be fed to a fuel cell to produce an electrical output. The bio diesel or bioalcohol can also be used to produce electricity.

Abstract: A detector for detecting ionizing radiation comprises a scintillator 10 selected to emit light in response to incidence thereon of radiation to be detected, at least one detector 16 for detecting said emitted light, and at least one optical waveguide 12 for transmitting said emitted light to said detector 16. The optical waveguide typically comprises a flexible solid or hollow fiber that can be incorporated into a flexible mat or into a fiber-reinforced structure, so that the detector is integrated therewith.