Patents by Inventor Philip Bufler

Philip Bufler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
    Patent number: 7820156
    Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: October 26, 2010
    Assignee: Ares Trading S.A.
    Inventors: Charles A Dinarello, Soo-Hyun Kim, Philip Bufler
  • METHOD OF TREATMENT USING A CYTOKINE ABLE TO BIND IL-18BP TO INHIBIT THE ACTIVITY OF A SECOND CYTOKINE
    Publication number: 20090074710
    Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 19, 2009
    Applicant: ARES TRADING S.A.
    Inventors: Charles A. Dinarello, Soo-Hyun Kim, Philip Bufler
  • Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
    Patent number: 7279155
    Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: October 9, 2007
    Assignee: Ares Trading S.A.
    Inventors: Charles A. Dinarello, Soo-Hyun Kim, Philip Bufler
  • Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs
    Publication number: 20040157930
    Abstract: The use of derivatives of hydroxamic acid having histone deacetylase enzyme-inhibiting activity for the preparation of anti-inflammatory medicaments is disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: August 12, 2004
    Inventors: Paolo Mascagni, Flavio Leoni, Giulia Porro, Paolo Pagani, Giancarlo Dona, Pietro Pozzi, Charles Dinarello, Giamila Fantuzzi, Britta Siegmund, Leonid Reznikov, Philip Bufler, Soo Hyun Kim, Benjamin Pomeranz
  • Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
    Publication number: 20040120923
    Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
    Type: Application
    Filed: October 3, 2003
    Publication date: June 24, 2004
    Applicant: ARES Trading S.A.
    Inventors: Charles A. Dinarello, Soo-Hyun Kim, Philip Bufler