Patents by Inventor Philip C. Bevilacqua

Philip C. Bevilacqua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sensitive and Accurate Genome-wide Profiling of RNA Structure In Vivo
    Publication number: 20220267838
    Abstract: The invention provides improved methods for determining the structure of RNA molecules with increased sensitivity, improved data quality, reduced ligation bias, and improved read coverage, incorporating the removal of undesired bi-products and ligation using a fast, efficient, and low-sequence bias hybridization-ligation method.
    Type: Application
    Filed: November 13, 2018
    Publication date: August 25, 2022
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Zhao Su, Laura Ritchey, David Mitchell
  • Low sequence bias single-stranded DNA ligation
    Patent number: 10640828
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 5, 2020
    Assignee: The Penn State Research Foundation
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low Sequence Bias Single-Stranded DNA Ligation
    Publication number: 20180030494
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 1, 2018
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low sequence bias single-stranded DNA ligation
    Patent number: 9816120
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: November 14, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low Sequence Bias Single-Stranded DNA Ligation
    Publication number: 20140193860
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Application
    Filed: January 9, 2014
    Publication date: July 10, 2014
    Applicant: The Penn State Research Foundation
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok