Patents by Inventor Philip C. Gevas

Philip C. Gevas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination treatment of pancreatic cancer
    Patent number: 8388966
    Abstract: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: March 5, 2013
    Assignee: Cancer Advances, Inc.
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Combination therapy for the treatment of tumors
    Patent number: 8343930
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: January 1, 2013
    Assignee: Cancer Advances, Inc.
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • TREATMENT AND PREVENTION OF CANCEROUS AND PRE-CANCEROUS CONDITIONS OF THE LIVER, LUNG AND ESOPHAGUS
    Publication number: 20110117108
    Abstract: The invention relates to the treatment and/or prevention of cancerous and/or, precancerous conditions of the liver, lung and esophagus by actively and/or passively immunizing a patient against the peptide hormone gastrin and/or a gastrin receptor, e.g., the CCK-B/gastrin receptor. The immunizations of the invention may be employed as a monotherapy, an adjunctive therapy, or as part of a combination therapy.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Applicant: Cancer Advances, Inc.
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes
  • COMBINATION THERAPY FOR THE TREATMENT OF TUMORS
    Publication number: 20100129382
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Application
    Filed: January 25, 2010
    Publication date: May 27, 2010
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • Combination therapy for the treatment of tumors
    Publication number: 20090191232
    Abstract: The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
    Type: Application
    Filed: November 25, 2008
    Publication date: July 30, 2009
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Susan A. Watson, Dov Michaeli
  • Combination treatment of pancreatic cancer
    Publication number: 20090004200
    Abstract: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
    Type: Application
    Filed: August 8, 2008
    Publication date: January 1, 2009
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Immunogenic compositions against gastrin peptides
    Patent number: 6861510
    Abstract: Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 1, 2005
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Combination treatment of pancreatic cancer
    Publication number: 20030091574
    Abstract: A combination for use in the treatment of pancreatic cancer comprising:
    Type: Application
    Filed: March 22, 2002
    Publication date: May 15, 2003
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Method for the treatment of gastroesophageal reflux disease
    Publication number: 20030068326
    Abstract: A method for the treatment of gastroesophageal reflux disease comprising a combination of active immunization with an anti-gastrin immunogenic composition with an antagonist which blocks or inhibits the gastric acid pump activity; or alternatively administering purified anti-gastrin antibodies with a H2 antagonist or proton pump inhibitor of the gastric acid producing enzyme system.
    Type: Application
    Filed: December 6, 2002
    Publication date: April 10, 2003
    Applicant: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen Karr, Dov Michaeli
  • Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
    Publication number: 20030021786
    Abstract: The invention relates to the treatment and/or prevention of cancerous and/or pre-cancerous conditions of the liver, lung and esophagus by actively and/or passively immunizing a patient against the peptide hormone gastrin and/or a gastrin receptor, e.g., the CCK-B/gastrin receptor. The immunizations of the invention may be employed as a monotherapy, an adjunctive therapy, or as part of a combination therapy.
    Type: Application
    Filed: July 9, 2002
    Publication date: January 30, 2003
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes
  • Method for the treatment and prevention of gastric and duodenal ulcer
    Patent number: 5866128
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin
    Patent number: 5785970
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 28, 1998
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5622702
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: April 22, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Methods for the preparation of immunogens against gastrin
    Patent number: 5609870
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: March 11, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against gastrin peptides
    Patent number: 5607676
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: March 4, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against human gastrin 17
    Patent number: 5468494
    Abstract: An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ser-Ser-Pro-Pro-Pro-Pro-Cys (SEQ ID NO.: 1) coupled to an immunogenic carrier and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: November 21, 1995
    Assignee: Aphton Corp.
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Dov Michaeli, Robert Scibienski
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5023077
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg