Abstract: Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.

Abstract: A method of preparation of crystalline aripiprazole monohydrate includes the use of solution enhanced dispersion by supercritical fluid. Specifically, water is introduced to a stream of supercritical fluid which is then allowed to mix with a stream including a mixture including aripiprazole and a solvent. The mixing results in the substantially simultaneous dispersion and extraction of the aripiprazole from the mixture by the supercritical fluid.