Abstract: A composition comprising a solution comprising an active pharmaceutical ingredient comprising an anticholinergic agent, such as ipratropium bromide, and a propellant comprising HFA-152a, HFO-1234ze(E), or both. A metered dose inhaler comprising a metering valve a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises said composition.

Abstract: A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.

Abstract: Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a metering valve, a canister, and an actuator having an actuator nozzle. The canister includes a formulation having greater than 70% by weight of HFO-1234ze(E), and at least one active pharmaceutical ingredient suspended in the formulation to form a suspension.

Abstract: Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.

Abstract: A method of preparation of crystalline aripiprazole monohydrate includes the use of solution enhanced dispersion by supercritical fluid. Specifically, water is introduced to a stream of supercritical fluid which is then allowed to mix with a stream including a mixture including aripiprazole and a solvent. The mixing results in the substantially simultaneous dispersion and extraction of the aripiprazole from the mixture by the supercritical fluid.