Patents by Inventor Philip Cornwall

Philip Cornwall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoxazinone amides as mineralocorticoid receptor modulators
    Patent number: 10017502
    Abstract: Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: July 10, 2018
    Assignee: AstraZeneca AB
    Inventors: Gavin O'Mahony, Michael Kossenjans, Karl Edman, Johan Kajanus, Carl Anders Hogner, Philip Cornwall, Andrew Turner
  • BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS
    Publication number: 20170217945
    Abstract: Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
    Type: Application
    Filed: June 26, 2015
    Publication date: August 3, 2017
    Applicant: AstraZeneca AB
    Inventors: Gavin O'Mahony, Michael Kossenjans, Karl Edman, Johan Kajanus, Carl Anders Hogner, Philip Cornwall, Andrew Turner
  • Benzoxazinone amides as mineralocorticoid receptor modulators
    Patent number: 9394291
    Abstract: Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: July 19, 2016
    Assignee: AstraZeneca AB
    Inventors: Gavin O'Mahony, Michael Kossenjans, Karl Edman, Johan Kajanus, Karl Anders Hogner, Philip Cornwall, Andrew Turner
  • Process
    Publication number: 20160002261
    Abstract: Processes for the preparation of the compound of formula II and intermediate compounds for use in the processes.
    Type: Application
    Filed: September 17, 2015
    Publication date: January 7, 2016
    Inventors: Neil Barnwell, Philip Cornwall, Duncan Michael Gill, Gareth P. Howell, Rebecca Elizabeth Meadows, Eric Merifield, Christopher William Mitchell, Andiappan Murugan, Philip O Keefe, Zakariya Mohamed Patel, James Barry Rose, John Singleton, Jane Withnall
  • BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS
    Publication number: 20150376170
    Abstract: Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 31, 2015
    Applicant: ASTRAZENECA AB
    Inventors: Gavin O'MAHONY, Michael KOSSENJANS, Karl EDMAN, Johan KAJANUS, Karl Anders HOGNER, Philip CORNWALL, Andrew TURNER
  • PROCESS
    Publication number: 20140364601
    Abstract: Processes for the preparation of the compound of formula (II) and intermediate compounds for use in the processes.
    Type: Application
    Filed: May 11, 2012
    Publication date: December 11, 2014
    Applicant: ASTRAZENECA AB
    Inventors: Neil Barnwell, Philip Cornwall, Duncan Michael Gill, Gareth P. Howell, Rebecca Elizabeth Meadows, Andiappan Murugan, Philip O'Keefe, John Singleton, Jane Withnall, Eric Merifield, Christopher William Mitchell, Zakariya Mohamed Patel, James Barry Rose
  • Process to prepare sulfonyl chloride derivatives
    Patent number: 7772403
    Abstract: A novel process for the preparation of hydantoin sulfonyl chlorides of general formula (I) wherein R and n are as specified in the description, and certain novel intermediates thereto, are disclosed.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: August 10, 2010
    Assignee: AstraZeneca AB
    Inventors: Philip Cornwall, Daniel Horner
  • Process for making phenoxy benzamide compounds
    Patent number: 7700640
    Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: April 20, 2010
    Assignee: AstraZeneca AB
    Inventors: Philip Cornwall, David Simon Ennis, Melvyn Edward Giles, Jacob Robert James Perkins, Shelly Louise Jenkin, Jeremy Stephen Parker, Bharti Patel
  • Process for the Preparation of Substituted 2-Acetylamino-Alkoxyphenyl
    Publication number: 20100041905
    Abstract: The present invention relates to a novel process for the preparation of compounds of formula (V) wherein X, Q, R1, R1a and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 18, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Debra Ainge, Philip Cornwall, Duncan Michael Gill, Luis Manuel Vaz
  • Process to Prepare Sulfonyl Chloride Derivatives
    Publication number: 20090054659
    Abstract: A novel process for the preparation of hydantoin sulfonyl chlorides of general formula (I) wherein R and n are as specified in the description, and certain novel intermediates thereto, are disclosed.
    Type: Application
    Filed: March 15, 2007
    Publication date: February 26, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Philip Cornwall, Daniel Horner
  • Process for Making Phenoxy Benzamide Compounds
    Publication number: 20080200694
    Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 21, 2008
    Inventors: Philip Cornwall, David Simon Ennis, Melvyn Edward Giles, Jacob Robert James Perkins, Shelly Louise Jenkin, Jeremy Stephen Parker, Bharti Patel
  • Novel Process 1
    Publication number: 20080064884
    Abstract: The present invention relates to a novel process for the preparation of compounds of formula (I) wherein X, Q, R1 and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents. The invention further relates to novel intermediates useful in the preparation of the therapeutic agents.
    Type: Application
    Filed: May 3, 2007
    Publication date: March 13, 2008
    Applicant: AstraZeneca AB
    Inventors: Debra Ainge, Philip Cornwall, Duncan Michael Gill, Vinod Kumar, Luis Manuel Vaz, Philip O'Keefe, Rhona Sinclair, Edward Laurence Way
  • Process for the preparation of nizatidine
    Patent number: 6069256
    Abstract: The present invention relates to a novel process for the preparation of nizatidine, N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2 -nitro-1,1-ethenediamine, and pharmaceutically acceptable salts thereof, comprising reacting a compound of formula II ##STR1## with a compound of formula III ##STR2## or a salt thereof, in which X represents a leaving group, in the presence of methylamine in the presence of an inert diluent.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: May 30, 2000
    Assignee: KNOLL Aktiengesellschaft
    Inventor: Philip Cornwall