Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

Abstract: The present invention is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract: There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

Abstract: Coatings which are applied to a component have to be removed again in a complex way in certain regions, since a coating was not desired to be present in those regions. The subsequent removal of this layer adversely affects the component, for example its geometry. The method according to the invention for coating a component includes a masking which at least partially comprises a ceramic powder and can therefore easily be removed after the component has been coated.

Abstract: A method of requesting video data distributed across a plurality of video servers (210-21N) connected to a communications network (120) is disclosed. A request (e.g., 1000) is transmitted to one of the video servers (e.g., 210). The request (1000) includes at least time information about at least a first portion of the video data. The first portion of video data is received from the video server (210). A redirection message (e.g., 1008) is also received from the video server (210). The redirection message (1008) specifies a next one of the video servers (210) containing a temporally adjacent further portion of the video data.

Abstract: Process and apparatus for producing a turbine component, turbine component and use of the apparatus Turbine components have to withstand high thermal and mechanical loads. It therefore proves advantageous for them to be made from a material with a preferred crystal orientation. Hitherto, the turbine components with a preferred crystal orientation have been produced as a single piece, with relatively high scrap rates. The proposed concept makes it possible to produce a preferred turbine component (9, 10) in a particularly simple way by assembling a turbine component (9, 10) at least from a first base part (1) and a build-up material (8), the subregion (7) of the joining zone having a preferred crystal orientation (2), so that disadvantageous properties of a joining zone without a preferred crystal orientation (2) which have hitherto been encountered are avoided.

Abstract: There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

Abstract: An improved book holding device is disclosed that enables a user to carry a plurality of books as well as related articles such as electronic devices, calculators, cell phones, electronic organizers, PDAs, digital music players and the like. The apparatus features an “x” shaped sheeted material having elongated straps. One of the straps carries a larger pouch that has a length that is about equal to or greater than the half of the length of its strap. Smaller pouches can be provided for holding smaller articles.

Abstract: Methods according to prior art for producing three-dimensional molded bodies generally require outer molds which define the geometry of a component to be produced. The inventive method for producing three-dimensional molded bodies renders one such mold redundant. The geometry of a component to be produced is defined by a pre-determined laser guidance or by the geometry of the partial quantities used.

Abstract: Masking layers for components according to the prior art react with the base material of the component and/or are difficult to remove again. The component according to the invention has a masking layer which can very easily be removed following coating of the components, since on the one hand the bonding between the masking layer and the base material of the component is poor, or the masking layer can easily be removed through penetration of a liquid.

Abstract: On account of their type of coating, layer systems of the prior art often exhibit poor adhesion to the substrate. If the components are subject to high mechanical stresses, the layer can then become detached. The layer system according to the invention has separately produced anchoring means which allow stronger attachment to the substrate than the attachment of the outer layer to the substrate.

Abstract: In the case of the epitaxial growth according to the prior art, a number o strips often have to be produced in a plane in order to restore an area to be repaired. This leads to overlapping and misorientation of the crystalline structures. In the case of the method according to the invention, the strip is of such a width that no overlapping occurs, since the width is adapted to the contour of the area to be repaired.

Abstract: A method for removing a layer area of a component in which the component is firstly treated in at least one salt bath, and then, in a further method step, treated at least once in an acid bath. The method can include adding sodium oxide to a salt bath as an oxygen donor treating the component with a salt bath wherein the salt bath is selected from the group consisting of: sodium hydroxide and potassium hydroxide and treating the component with an acid bath wherein the acid bath is selected from the group consisting of: nitric acid and phosphoric acid.

Abstract: On account of their type of coating, layer systems of the prior art often exhibit poor adhesion to the substrate. If the components are subject to high mechanical stresses, the layer can then become detached. The layer system according to the invention has separately produced anchoring means which allow stronger attachment to the substrate than the attachment of the outer layer to the substrate.

Abstract: On account of their form of coating, layer systems according to the prior art often only have a low level of attachment to the substrate. The layer may then become detached in the event of high mechanical loads being applied to the components. The layer system according to the invention has separately produced anchoring means which are more strongly attached to the substrate than the attachment of the layer to the substrate.

Abstract: Masking layers for components according to the prior art react with the base material of the component and/or are difficult to remove again. The component according to the invention has a masking layer which can very easily be removed following coating of the components, since on the one hand the bonding between the masking layer and the base material of the component is poor, or the masking layer can easily be removed through penetration of a liquid.

Abstract: A contaminant-resistant bearing assembly includes a multi-lip seal with an extended shroud supported from the outer ring and projecting adjacent a stepped inner ring shoulder. A steel slinger supported from the inner ring is offset outwardly adjacent the shroud and includes a radially outer edge terminating closely adjacent the connection of the seal shroud to the outer ring. The slinger includes an outer portion angled inwardly from the radial direction and supporting a lip seal which contacts an angled portion of the seal shroud at a central location between the rings. A primary step machined on the inner ring prevents the slinger from being pushed into the seal.

Abstract: Prior art methods for removing a layer area of a component (stripping) lead to poor results since a removal, for example, ensues in a nonuniform manner. In addition, these prior art methods are time intensive. An inventive method for removing a layer area of a component consists of firstly treating the layer areas to be removed with a salt solution and then with acid, whereby in an intermediate or final step, the component is treated with a complexing agent.

Abstract: Alloys known in prior art cannot be processed well enough for producing a part. According to the inventive method, the part is subjected to a thermal treatment in an intermediate step, which improves the processability thereof.