Abstract: The present disclosure relates to immunomodulatory fusion proteins containing an extracellular binding domain and an intracellular signaling domain, wherein binding of a target can generate a modulatory signal in a host cell, such as a T cell. The present disclosure also relates to uses of immune cells expressing such immunomodulatory fusion proteins to treat certain diseases, such as cancer or infectious disease.

Abstract: A method of performing automatic ion control for mass spectrometry includes acquiring, by charge detection mass spectrometry, a mass spectrum comprising a plurality of peaks representing intensity as a function of mass-to-charge ratio (m/z) of a population of ions analyzed by a mass analyzer during an acquisition event. Based on the mass spectrum, a measured signal density of a selected m/z range of the mass spectrum is determined. An ion population control parameter for a subsequent acquisition event is set based on the measured signal density and a target signal density. The ion population control parameter regulates a population of ions analyzed by the mass analyzer during the subsequent acquisition event.

Abstract: Embodiments are directed to managing access to network resources. A first mesh agent may be configured to provide a client with access to a resource via an overlay network. The first mesh agent may determine an identity and an activity associated with requests such that the identity corresponds to an entity that may be authenticated to access the overlay network and the resource. A policy container associated with the activity may be determined based on characteristics of the requests such that the policy container may include policies associated with the activity. The requests may be validated based on the policies included in the policy container such that the validated requests may be forwarded to the resource and invalidated requests may be discarded and such that persistence of the connection may be maintained during the validation.

Abstract: A method of constructing a storage well for an energy production system comprising determining a fractured volume of the storage well with a curved wellbore by inputting the curved wellbore path, a set of formation properties, and a fracturing operation, into a fracturing model. The curved wellbore path can promote fracture interference between fracture stresses extending from the storage wellbore path. The energy production system can inject a volume of compressed gas into the fractured volume via the storage wellbore or produce a volume of gas from the fractured volume. A design process can iterate the curved wellbore path of the storage well to create a fractured volume of the storage well greater than a threshold value.

Abstract: A method of producing hydrogen downhole in a subterranean reaction zone that employs fracturing a subterranean formation to provide fractures in the subterranean formation (e.g., to produce the subterranean reaction zone comprising fracture volume provided by the fractures), wherein the subterranean comprises a tight formation, and introducing one of more reactants downhole into the fractures (e.g., into the subterranean reaction zone), whereby hydrogen is produced by reaction of the one or more reactants in situ in the fractures (e.g., in situ in the reaction zone).

Abstract: A method including reacting carbon dioxide from exhaust gas produced at a wellsite to produce a solid metal carbonate, and microwaving the solid metal carbonate to produce recovered carbon dioxide and solid metal alkaline. A system for carrying out the method is also provided.

Abstract: When conducting borehole operations, such as drilling, injection, or hydraulic fracturing, using a variable torque converter to reduce the torque force output of a constant speed engine or motor would enable a more efficient use of resources and lower costs due to less wear and tear on equipment. The fluid pump system at the borehole can utilize the variable torque converter, receiving operating commands from a control system, to reduce the torque delivered to the fluid pump to maintain operational parameters, such as a rate of change of load on the engine or motor, a maximum fluid pressure measured at the pump or downhole, or other operational parameters. The variable torque converter can be part of a transmission system, or be located before or after the transmission system. The variable torque converter can utilize torque oil or a magnetic system to control the torque force being delivered.

Abstract: The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as T cell receptors bind to a Ras antigen:HLA complex. Disclosed binding proteins are highly sensitive to antigen, capable of inducing activation of host T cells at low concentrations of peptide antigen. In certain embodiments, binding proteins of the present disclosure are non-alloreactive against, are substantially non-alloreactive against, and/or have a low risk of alloreactivity against (i) amino acid sequences from the human proteome and/or (ii) against human HLA alleles. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers.

Abstract: When conducting borehole operations, such as drilling, injection, or hydraulic fracturing, using a variable torque converter to reduce the torque force output of a constant speed engine or motor would enable a more efficient use of resources and lower costs due to less wear and tear on equipment. The fluid pump system at the borehole can utilize the variable torque converter, receiving operating commands from a control system, to reduce the torque delivered to the fluid pump to maintain operational parameters, such as a rate of change of load on the engine or motor, a maximum fluid pressure measured at the pump or downhole, or other operational parameters. The variable torque converter can be part of a transmission system, or be located before or after the transmission system. The variable torque converter can utilize torque oil or a magnetic system to control the torque force being delivered.

Abstract: Methods and compositions for modifying T-cells in which PD1 and/or CTLA-4 is repressed and/or inactivated using fusion proteins such as artificial transcription factors and nucleases.

Abstract: A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

Abstract: Embodiments are directed to managing interactions with applications. A plurality of interactions with the application that are enforced by the native security policies may be determined. A virtual policy interface may be generated to collect information associated with a plurality of other interactions with the application that may be unassociated with the native security policies. A virtual policy engine may be employed to perform further actions, including: determining activities based on the collected information associated with the plurality of other interactions; determining virtual security policies associated with the plurality of other interactions based on the activities.

Abstract: The present invention relates to articulating spacecraft chassis and methods of making and using same. The present invention relates to spacecraft chassis and methods of making and using same. Such spacecraft chassis have a dynamic movement capability that allows the spacecraft to alter its structure while still maintaining industry volumetric launch standards. This capability increases opens up a wide range of achievable volumetric states and increases the ability to meet mission requirements by introducing a new tunable parameter. In addition, the judicious selection of certain dynamic movement parameters can result increased payload capabilities and improved maneuverability.

Abstract: The present disclosure is directed to a lid component for use with a jar and a band. The jar and band may be a mason jar and a band for a mason jar. The lid component is made of an air-impermeable material and is dimensioned and configured to be releasably attachable to the jar by the band and to seal a wide mouth opening of the jar in an air-tight manner. The lid component comprises a one-way valve adapted to allow gas to escape from the jar while, at the same time, prevent air from entering the jar, when the lid component is releasably attached to the jar. The one-way valve comprises a bottom opening and a protruding top wall. The lid component further comprises a sealing wall that extends radially outwardly from the bottom opening. The sealing wall is substantially flat.

Abstract: The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.

Abstract: Embodiments are directed to managing access to network resources. A first mesh agent may be configured to provide a client with access to a resource via an overlay network. The first mesh agent may determine an identity and an activity associated with requests such that the identity corresponds to an entity that may be authenticated to access the overlay network and the resource. A policy container associated with the activity may be determined based on characteristics of the requests such that the policy container may include policies associated with the activity. The requests may be validated based on the policies included in the policy container such that the validated requests may be forwarded to the resource and invalidated requests may be discarded and such that persistence of the connection may be maintained during the validation.

Abstract: Described herein are immunomodulatory fusion proteins containing an extracellular binding domain and an intracellular signaling domain, wherein binding of a target can generate a modulatory signal in a host cell, such as a T cell. Some immunomodulatory fusion proteins as described comprise a SIRP? extracellular component and hydrophobic and intracellular components comprising transmembrane and/or signaling domains of a CD28, respectively. Such fusion proteins are capable of delivering a positive or costimulatory signal in response to a binding event that in a natural setting would result in an inhibitory signal. Uses of immune cells expressing such immunomodulatory fusion proteins to treat certain diseases, such as cancer or infectious disease, are also described.

Abstract: Embodiments are directed to managing interactions with applications. A plurality of interactions with the application that are enforced by the native security policies may be determined. A virtual policy interface may be generated to collect information associated with a plurality of other interactions with the application that may be unassociated with the native security policies. A virtual policy engine may be employed to perform further actions, including: determining activities based on the collected information associated with the plurality of other interactions'; determining virtual security policies associated with the plurality of other interactions based on the activities.

Abstract: A method may include: providing a methanol fuel cell and methanol; reacting the methanol in the methanol fuel cell to generate at least electricity; powering wellbore equipment at least in part using the electricity generated in the methanol fuel cell; and performing a wellbore operation using the wellbore equipment.

Abstract: A water play area installation that includes an underground reservoir tank installed at least partially underground. The water play area installation also includes a water flow regulation hub integrated into the water reservoir tank.