Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.

Abstract: A frit comprising a plurality of grooves; a drain hole; a transverse crossing lane; wherein said plurality of grooves are substantially parallel to one another and extend longitudinally across said frit; wherein said plurality of grooves comprise at least two different lengths; wherein said transverse crossing lane is substantially perpendicular to said plurality of grooves; wherein said drain hole is located within said transverse crossing lane; wherein said drain hole is located at a center of said transverse crossing lane.

Abstract: A consumable device comprising a substantially rigid two-layer main body, window for receiving a membrane, and an electronic tag for storing and communicating information, wherein the consumable device is configured to be received by a molecular filtration device for the purpose of creating a channel within which a solution may be inserted to purify molecules or exchange a buffer solution.

Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.

Abstract: A frit comprising a plurality of grooves; a drain hole; a transverse crossing lane; wherein said plurality of grooves are substantially parallel to one another and extend longitudinally across said frit; wherein said plurality of grooves comprise at least two different lengths; wherein said transverse crossing lane is substantially perpendicular to said plurality of grooves; wherein said drain hole is located within said transverse crossing lane; wherein said drain hole is located at a center of said transverse crossing lane.

Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a substantially pure solution comprising the desired molecule.

Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a substantially pure solution comprising the desired molecule.

Abstract: Disclosed herein is a system and method for analyzing a specimen containing the proteome by mass spectrometry. The system includes a protein separation module; a matrix processing module; and a mass spectrometer module. The protein separation module, the matrix processing module and the mass spectrometer are in fluid communication with one another.

Abstract: The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electrospray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described.

Abstract: The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electro-spray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described.

Abstract: A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).

Abstract: A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).