Patents by Inventor Philip D. Heppner

Philip D. Heppner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl substituted imidazoquinolines
    Patent number: 7598382
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: October 6, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Tushar Kshirsagar, Philip D. Heppner, Bryon A. Merrill, Michael E. Danielson, John F. Gerster, Chad A. Haraldson, Sarah Johannessen, Maureen A. Kavanagh, Kyle J. Lindstrom, Michael J. Rice, David J. Squire, Sarah A. Strong, Joshua R. Wurst
  • SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS
    Publication number: 20090221551
    Abstract: [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 3, 2009
    Inventors: Tushar A. Kshirsagar, Karl J. Manske, Larry R. Krepski, Joan T. Moseman, George W. Griesgraber, Sarah Johannessen Slania, Philip D. Heppner
  • HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS
    Publication number: 20090221556
    Abstract: 1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: November 3, 2006
    Publication date: September 3, 2009
    Inventors: Tushar A. Kshirsagar, Philip D. Heppner, Scott E. Langer
  • Pyrazolopyridines and analogs thereof
    Patent number: 7544697
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: June 9, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Michael E. Danielson, John F. Gerster, Shri Niwas, Ryan B. Prince, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Joan T. Moseman, Matthew R. Radmer, Maureen A. Kavanagh, Sarah A. Strong, Jason D. Bonk
  • HYDROXYLAMINE SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20090105295
    Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: November 12, 2004
    Publication date: April 23, 2009
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, Gregory D. Lundquist, JR., David T. Amos, Joseph F. Dellaria, JR., Bernhard M. Zimmermann, Philip D. Heppner
  • Substituted Imidazoquinolines and Imidazonaphthyridines
    Publication number: 20090099161
    Abstract: Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 10, 2006
    Publication date: April 16, 2009
    Applicant: Coley Pharmaceutial Group, Inc.
    Inventors: Michael J. Rice, Chad A. Haraldson, John F. Gerster, Joshua R. Wurst, Philip D. Heppner, Bryon A. Merrill, Tushar A. Kshirsagar
  • Pyrazolopyridines and Analogs Thereof
    Publication number: 20090075980
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: March 31, 2006
    Publication date: March 19, 2009
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Michael E. Danielson, John F. Gerster, Shri Niwas, Ryan B. Prince, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Joan T. Moseman, Matthew R. Radmer, Maureen A. Kavanagh, Sarah A. Strong, Jason D. Bonk
  • Hydroxyalkyl Substituted Imidazoquinoline Compounds and Methods
    Publication number: 20090069314
    Abstract: Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-? biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 22, 2006
    Publication date: March 12, 2009
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, Bryon A. Merrill, Shri Niwas, Gregory D. Lundquist, JR., Philip D. Heppner, Michael E. Danielson
  • Pyrazolo[3,4-c]Quinolines, Pyrazolo[3,4-c]Naphthyridines, Analogs Thereof, and Methods
    Publication number: 20090069299
    Abstract: Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.
    Type: Application
    Filed: March 31, 2006
    Publication date: March 12, 2009
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Bryon A. Merrill, Michael E. Danielson, David S. Hays, David T. Amos, Philip D. Heppner, Tushar A. Kshirsagar, Gregory D. Lundquist, JR., William H. Moser
  • OXIME SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20090042925
    Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: November 12, 2004
    Publication date: February 12, 2009
    Inventors: Tushar A. Kshirsagar, Gregory D. Lundquist, David T. Amos, Joseph F. Dellaria, JR., Bernhard M. Zimmermann, Philip D. Heppner
  • Method of Preferentially Inducing the Biosynthesis of Interferon
    Publication number: 20090030031
    Abstract: A method of preferentially inducing IFN-? biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-? biosynthesis in an animal are disclosed.
    Type: Application
    Filed: February 22, 2006
    Publication date: January 29, 2009
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Tushar A. Kshirsagar, Bryon A. Merrill, Scott E. Langer, Kyle J. Lindstrom, Sarah C. Slania, Gregory J. Marszalek, Joshua R. Wurst, Karl J. Manske, Shri Niwas, Gregory D. Lundquist, JR., Philip D. Heppner, George W. Griesgraber, Michael E. Danielson
  • Hydroxyalkyl Substituted Imidazoquinolines
    Publication number: 20090029988
    Abstract: Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-? biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 22, 2006
    Publication date: January 29, 2009
    Applicant: Coley Pharmaceutical Grop, Inc.
    Inventors: Tushar A. Kshirsagar, Bryon A. Merrill, Scott E. Langer, Kyle J. Lindstrom, Sarah JC. Slania, Gregory J. Marszalek, Karl J. Manske, Philip D. Heppner, Gregory D. Lundquist, JR.
  • 2-Amino 1H-Imidazo Ring Systems and Methods
    Publication number: 20090023720
    Abstract: 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: September 1, 2005
    Publication date: January 22, 2009
    Inventors: Tushar A. Kshirsagar, Scott E. Langer, Shri Niwas, Philip D. Heppner, David T. Amos
  • Aryloxy and Arylalkyleneoxy Substituted Imidazoquinolines
    Publication number: 20090018122
    Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: August 27, 2004
    Publication date: January 15, 2009
    Inventors: Kyle J. Lindstrom, Hugues M.H. Martin, Bryon A. Merrill, Michael J. Rice, Joshua R. Wurst, Chad A. Haraldson, Tushar A. Kshirsagar, Philip D. Heppner, Shri Niwas, George W. Griesgraber, Matthew R. Radmer
  • Substituted Fused [1,2]Imidazo[4,5-C] Ring Compounds and Methods
    Publication number: 20090005371
    Abstract: Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 10, 2006
    Publication date: January 1, 2009
    Inventors: Michael J. Rice, Bryon A. Merrill, Philip D. Heppner
  • Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines
    Publication number: 20080318998
    Abstract: Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 8, 2006
    Publication date: December 25, 2008
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Ryan B. Prince, Bryon A. Merrill, Philip D. Heppner, Tushar M. Kshirsagar, Joshua R. Wurst, Karl J. Manske, Michael J. Rice
  • SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20080306252
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 11, 2008
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Stephen L. Crooks, George W. Griesgraber, Philip D. Heppner, Bryon A. Merrill, Ralph R. Roberts, Ai-Ping Wei
  • Hydroxylamine Substituted Imidazoquinolines
    Publication number: 20080114019
    Abstract: Imidazoquinoline compounds with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: August 12, 2004
    Publication date: May 15, 2008
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, David T. Amos, Joseph F. Dellaria, Jr., Philip D. Heppner, Scott E. Langer, Bernhard M. Zimmermann
  • Intermediates for imidazonaphthyridines
    Patent number: 7335773
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: February 26, 2008
    Assignee: Graceway Pharmaceuticals, LLC
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Ether substituted imidazopyridines
    Patent number: 7220758
    Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: May 22, 2007
    Assignee: 3M Innovative Properties Company
    Inventors: Joseph F. Dellaria, Kyle J. Lindstrom, Luke T. Dressel, Philip D. Heppner, John R. Jacobsen, Joan T. Moseman, William H. Moser, Matthew R. Radmer, Doris Stoermer