Patents by Inventor Philip D. Laible
Philip D. Laible has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11785943Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.Type: GrantFiled: September 21, 2018Date of Patent: October 17, 2023Assignee: UChicago Argonne, LLCInventors: Philip D. Laible, Martyna Michalska, Philippe Noirot, Ralu Divan, Igor Aronson, Andrey Sokolov
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Patent number: 11247896Abstract: A material with a nanotexture comprising structures extending from a substrate. The structures are modified by coating the nanotexture with a protective coating and partially removing the coating, exposing a portion of the structure for functionalization.Type: GrantFiled: July 30, 2019Date of Patent: February 15, 2022Assignee: UChicago Argonne, LLCInventors: Martyna Michalska, Philip D. Laible, Ralu Divan
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Publication number: 20220001352Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.Type: ApplicationFiled: July 2, 2021Publication date: January 6, 2022Applicant: UCHICAGO ARGONNE, LLCInventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
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Patent number: 11052374Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.Type: GrantFiled: December 20, 2018Date of Patent: July 6, 2021Assignee: UChicago Argonne, LLCInventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
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Publication number: 20200197900Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.Type: ApplicationFiled: December 20, 2018Publication date: June 25, 2020Applicant: UCHICAGO ARGONNE, LLCInventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
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Publication number: 20200039819Abstract: A material with a nanotexture comprising structures extending from a substrate. The structures are modified by coating the nanotexture with a protective coating and partially removing the coating, exposing a portion of the structure for functionalization.Type: ApplicationFiled: July 30, 2019Publication date: February 6, 2020Applicant: UCHICAGO ARGONNE, LLCInventors: Martyna Michalska, Philip D. Laible, Ralu Divan
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Publication number: 20190093150Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.Type: ApplicationFiled: September 21, 2018Publication date: March 28, 2019Applicant: UCHICAGO ARGONNE, LLCInventors: Philip D. LAIBLE, Martyna MICHALSKA, Philippe NOIROT, Ralu DIVAN, Igor ARONSON, Andrey SOKOLOV
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Publication number: 20190090478Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.Type: ApplicationFiled: September 21, 2018Publication date: March 28, 2019Applicant: UCHICAGO ARGONNE, LLCInventors: Philip D. LAIBLE, Martyna MICHALSKA, Philippe NOIROT, Ralu DIVAN, Igor ARONSON, Andrey SOKOLOV
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Patent number: 9963709Abstract: The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.Type: GrantFiled: September 14, 2012Date of Patent: May 8, 2018Assignee: UCHICAGO ARGONNE, LLCInventors: Philip D. Laible, Deborah K. Hanson
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Patent number: 9441248Abstract: The invention provides for a novel type of biofuel; a method for cleaving anchors from photosynthetic organisms; and a method for producing biofuels using photosynthetic organisms, the method comprising identifying photosynthesis co-factors and their anchors in the organisms; modifying the organisms to increase production of the anchors; accumulating biomass of the organisms in growth media; and harvesting the anchors.Type: GrantFiled: June 13, 2011Date of Patent: September 13, 2016Assignee: UCHICAGO ARGONNE, LLCInventors: Philip D. Laible, Seth W. Snyder
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Publication number: 20140080176Abstract: The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.Type: ApplicationFiled: September 14, 2012Publication date: March 20, 2014Applicant: UCHICAGO ARGONNE, LLCInventors: Philip D. Laible, Deborah K. Hanson
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Patent number: 8455231Abstract: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of intracytoplasmic membranes from organism by modifying DNA to delete genes encoding functions of the organism not associated with the formation of the intracytoplasmic membranes; generating appropriate DNA or RNA templates that encode the target protein; and mixing the intracytoplasmic membranes with the template and a transcription/translation-competent cellular extract to cause simultaneous production of the membrane proteins and encapsulation of the membrane proteins within the intracytoplasmic membranes.Type: GrantFiled: February 8, 2010Date of Patent: June 4, 2013Assignee: Uchicago Argonne, LLCInventors: Philip D. Laible, Deborah K. Hanson
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Patent number: 8263754Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.Type: GrantFiled: April 8, 2009Date of Patent: September 11, 2012Assignees: Wisconsin Alumni Research Foundation, UChicago Argonne, LLCInventors: Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
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Patent number: 8168746Abstract: The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.Type: GrantFiled: April 18, 2008Date of Patent: May 1, 2012Assignee: UChicago Argonne, LLCInventors: Millicent A. Firestone, Philip D. Laible
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Publication number: 20110302830Abstract: The invention provides for a novel type of biofuel; a method for cleaving anchors from photosynthetic organisms; and a method for producing biofuels using photosynthetic organisms, the method comprising identifying photosynthesis co-factors and their anchors in the organisms; modifying the organisms to increase production of the anchors; accumulating biomass of the organisms in growth media; and harvesting the anchors.Type: ApplicationFiled: June 13, 2011Publication date: December 15, 2011Applicant: UCHICAGO ARGONNE, LLCInventors: Philip D. Laible, Seth W. Snyder
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Publication number: 20110244524Abstract: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of intracytoplasmic membranes from organism by modifying DNA to delete genes encoding functions of the organism not associated with the formation of the intracytoplasmic membranes; generating appropriate DNA or RNA templates that encode the target protein; and mixing the intracytoplasmic membranes with the template and a transcription/translation-competent cellular extract to cause simultaneous production of the membrane proteins and encapsulation of the membrane proteins within the intracytoplasmic membranes.Type: ApplicationFiled: February 8, 2010Publication date: October 6, 2011Inventors: Philip D. Laible, Deborah K. Hanson
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Publication number: 20090270598Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.Type: ApplicationFiled: April 8, 2009Publication date: October 29, 2009Applicant: WARF - Wisconsin Alumni Research FoundationInventors: Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
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Publication number: 20080319169Abstract: The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.Type: ApplicationFiled: April 18, 2008Publication date: December 25, 2008Inventors: Millicent A. Firestone, Philip D. Laible
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Patent number: 6465216Abstract: A method for expressing and purifying foreign proteins in photosynthetic organisms comprising the simultaneous expression of both the heterologous protein and a means for compartmentalizing or sequestering of the protein.Type: GrantFiled: February 1, 2001Date of Patent: October 15, 2002Assignee: University of ChicagoInventors: Philip D. Laible, Deborah K. Hanson
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Publication number: 20020102655Abstract: A method for expressing and purifying foreign proteins in photosynthetic organisms comprising the simultaneous expression of both the heterologous protein and a means for compartmentalizing or sequestering of the protein.Type: ApplicationFiled: February 1, 2001Publication date: August 1, 2002Inventors: Philip D. Laible, Deborah K. Hanson