Patents by Inventor Philip D. Laible

Philip D. Laible has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11785943
    Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 17, 2023
    Assignee: UChicago Argonne, LLC
    Inventors: Philip D. Laible, Martyna Michalska, Philippe Noirot, Ralu Divan, Igor Aronson, Andrey Sokolov
  • Patent number: 11247896
    Abstract: A material with a nanotexture comprising structures extending from a substrate. The structures are modified by coating the nanotexture with a protective coating and partially removing the coating, exposing a portion of the structure for functionalization.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: February 15, 2022
    Assignee: UChicago Argonne, LLC
    Inventors: Martyna Michalska, Philip D. Laible, Ralu Divan
  • Publication number: 20220001352
    Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.
    Type: Application
    Filed: July 2, 2021
    Publication date: January 6, 2022
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
  • Patent number: 11052374
    Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 6, 2021
    Assignee: UChicago Argonne, LLC
    Inventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
  • Publication number: 20200197900
    Abstract: A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 25, 2020
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Patricia Ignacio de Leon, Philip D. Laible, Mackenzie Elizabeth Meyer, Christopher R. Povinelli, Killian L. Tracey, Daniel Yoav Arenas
  • Publication number: 20200039819
    Abstract: A material with a nanotexture comprising structures extending from a substrate. The structures are modified by coating the nanotexture with a protective coating and partially removing the coating, exposing a portion of the structure for functionalization.
    Type: Application
    Filed: July 30, 2019
    Publication date: February 6, 2020
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Martyna Michalska, Philip D. Laible, Ralu Divan
  • Publication number: 20190093150
    Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 28, 2019
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. LAIBLE, Martyna MICHALSKA, Philippe NOIROT, Ralu DIVAN, Igor ARONSON, Andrey SOKOLOV
  • Publication number: 20190090478
    Abstract: A material with nanopillar structures extending from a substrate. The nanopillars are engageable by organisms to cause an interaction, such as cellular destruction.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 28, 2019
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. LAIBLE, Martyna MICHALSKA, Philippe NOIROT, Ralu DIVAN, Igor ARONSON, Andrey SOKOLOV
  • Patent number: 9963709
    Abstract: The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 8, 2018
    Assignee: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Patent number: 9441248
    Abstract: The invention provides for a novel type of biofuel; a method for cleaving anchors from photosynthetic organisms; and a method for producing biofuels using photosynthetic organisms, the method comprising identifying photosynthesis co-factors and their anchors in the organisms; modifying the organisms to increase production of the anchors; accumulating biomass of the organisms in growth media; and harvesting the anchors.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: September 13, 2016
    Assignee: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. Laible, Seth W. Snyder
  • Publication number: 20140080176
    Abstract: The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 20, 2014
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Patent number: 8455231
    Abstract: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of intracytoplasmic membranes from organism by modifying DNA to delete genes encoding functions of the organism not associated with the formation of the intracytoplasmic membranes; generating appropriate DNA or RNA templates that encode the target protein; and mixing the intracytoplasmic membranes with the template and a transcription/translation-competent cellular extract to cause simultaneous production of the membrane proteins and encapsulation of the membrane proteins within the intracytoplasmic membranes.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 4, 2013
    Assignee: Uchicago Argonne, LLC
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Patent number: 8263754
    Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: September 11, 2012
    Assignees: Wisconsin Alumni Research Foundation, UChicago Argonne, LLC
    Inventors: Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
  • Patent number: 8168746
    Abstract: The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: May 1, 2012
    Assignee: UChicago Argonne, LLC
    Inventors: Millicent A. Firestone, Philip D. Laible
  • Publication number: 20110302830
    Abstract: The invention provides for a novel type of biofuel; a method for cleaving anchors from photosynthetic organisms; and a method for producing biofuels using photosynthetic organisms, the method comprising identifying photosynthesis co-factors and their anchors in the organisms; modifying the organisms to increase production of the anchors; accumulating biomass of the organisms in growth media; and harvesting the anchors.
    Type: Application
    Filed: June 13, 2011
    Publication date: December 15, 2011
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Philip D. Laible, Seth W. Snyder
  • Publication number: 20110244524
    Abstract: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of intracytoplasmic membranes from organism by modifying DNA to delete genes encoding functions of the organism not associated with the formation of the intracytoplasmic membranes; generating appropriate DNA or RNA templates that encode the target protein; and mixing the intracytoplasmic membranes with the template and a transcription/translation-competent cellular extract to cause simultaneous production of the membrane proteins and encapsulation of the membrane proteins within the intracytoplasmic membranes.
    Type: Application
    Filed: February 8, 2010
    Publication date: October 6, 2011
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Publication number: 20090270598
    Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
    Type: Application
    Filed: April 8, 2009
    Publication date: October 29, 2009
    Applicant: WARF - Wisconsin Alumni Research Foundation
    Inventors: Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
  • Publication number: 20080319169
    Abstract: The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.
    Type: Application
    Filed: April 18, 2008
    Publication date: December 25, 2008
    Inventors: Millicent A. Firestone, Philip D. Laible
  • Patent number: 6465216
    Abstract: A method for expressing and purifying foreign proteins in photosynthetic organisms comprising the simultaneous expression of both the heterologous protein and a means for compartmentalizing or sequestering of the protein.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: October 15, 2002
    Assignee: University of Chicago
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Publication number: 20020102655
    Abstract: A method for expressing and purifying foreign proteins in photosynthetic organisms comprising the simultaneous expression of both the heterologous protein and a means for compartmentalizing or sequestering of the protein.
    Type: Application
    Filed: February 1, 2001
    Publication date: August 1, 2002
    Inventors: Philip D. Laible, Deborah K. Hanson