Abstract: An instrument includes a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to close off a fluidic channel in the body. A cartridge interface is configured to engage the cartridge.

Abstract: The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.

Abstract: An electrode array includes a body portion, at least one tail portion, at least one tissue surface contact, and at least one intratissue contact. The electrode array can provide stimulation or record signals from both the surface of a target tissue and within the target tissue. A system for tissue surface and intratissue signal recording and/or stimulation contains an electrode array, a controller or receiver, and at least one connection between the electrode array and the controller or receiver. A method of recording signals and/or stimulating tissue includes contacting the target tissue surface and target tissue interior with an electrode array and providing or recording an electrical, chemical, or optical signal.

Abstract: A lead assembly for networked implants may contain a controller, an implantable tissue contact system connected to the controller and including a plurality of leads, and a breakout connector connected to each of the plurality of leads, and further connected to a shared communication path. A physiological interface system may contain a controller and an implantable tissue contact system. Methods of treating a subject and monitoring a subject include transmitting signals between a controller and an implantable tissue contact system.

Abstract: The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.

Abstract: Existing approaches for deception detection are primarily based on polygraph systems that measure specific channels of physiology in highly structured interviews and that are interpreted by trained polygraph examiners. Existing approaches for predicting interviewer accuracy involve interviewers' own estimates of their performances which inevitably are biased. The methods and systems described herein provides objective, quantitative and automated metrics to detect deception and predict interviewer accuracy. Physiological information of the interviewer during the interview is recorded by at least a first sensor. The physiological information includes a time series of physiological data. An interview assessment is calculated by a computer. By processing the recorded physiological information, the interview assessment indicates at least one of whether a statement made by the interviewee is likely to be deceitful and whether the interviewer is likely to be accurate in estimating truthfulness of the interviewee.

Abstract: This invention provides systems and methods for using spatially localized sensor data to construct a multi-dimensional map of the location of key anatomical features, as well as systems and methods for utilizing this map to present location-based information to the surgeon and/or to an automated surgical navigation system. The location map is updated during surgery, so as to retain accuracy even in the presence of muscle-induced motion or deformation of the anatomy, as well as tissue location changes induced by translations or deformations induced by surgical dissection, surgical instrument contact, or biologically-induced tissue motion associated with activities such as respiration, anesthesia-induced gag reflex, blood flow/pulsation, and/or larger-scale changes in patient posture/positioning.

Abstract: A lead assembly for networked implants may contain a controller, an implantable tissue contact system connected to the controller and including a plurality of leads, and a breakout connector connected to each of the plurality of leads, and further connected to a shared communication path. A physiological interface system may contain a controller and an implantable tissue contact system. Methods of treating a subject and monitoring a subject include transmitting signals between a controller and an implantable tissue contact system.

Abstract: An electrode array includes a body portion, at least one tail portion, at least one tissue surface contact, and at least one intratissue contact. The electrode array can provide stimulation or record signals from both the surface of a target tissue and within the target tissue. A system for tissue surface and intratissue signal recording and/or stimulation contains an electrode array, a controller or receiver, and at least one connection between the electrode array and the controller or receiver. A method of recording signals and/or stimulating tissue includes contacting the target tissue surface and target tissue interior with an electrode array and providing or recording an electrical, chemical, or optical signal.

Abstract: A fundoscopy system comprises a fixture supporting optics configured to be mounted to a surface of a smartphone and align the optics with a pupil of a camera of the smartphone and to align a light guide with an illumination source of the smartphone. The light guide is configured to direct light from the illumination source into an eye of a subject disposed in front of the fixture. The fixture is further configured to direct light reflected from a retina of the eye through the optics and into the pupil of the camera of the smartphone.

Abstract: Existing approaches for deception detection are primarily based on polygraph systems that measure specific channels of physiology in highly structured interviews and that are interpreted by trained polygraph examiners. Existing approaches for predicting interviewer accuracy involve interviewers' own estimates of their performances which inevitably are biased. The methods and systems described herein provides objective, quantitative and automated metrics to detect deception and predict interviewer accuracy. Physiological information of the interviewer during the interview is recorded by at least a first sensor. The physiological information includes a time series of physiological data. An interview assessment is calculated by a computer. By processing the recorded physiological information, the interview assessment indicates at least one of whether a statement made by the interviewee is likely to be deceitful and whether the interviewer is likely to be accurate in estimating truthfulness of the interviewee.

Abstract: The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.