Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.

Abstract: Measurements of the mass and surface charge of microparticles are employed in the characterization of many types of colloidal dispersions. The suspended microchannel resonator (SMR) is capable of measuring individual particle masses with femtogram resolution. The high sensitivity of the SMR resonance frequency to changes in particle position in the SMR channel is employed to determine the electrophoretic mobility of discrete particles in an applied electric field. When an oscillating electric field is applied to the suspended microchannel, the transient resonance frequency shift corresponding to a particle transit can be analyzed to extract both the buoyant mass and electrophoretic mobility of each particle. These parameters, together with the mean particle density, can be used to compute the size, absolute mass, and surface charge of discrete particles.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Abstract: Measurements of the mass and surface charge of microparticles are employed in the characterization of many types of colloidal dispersions. The suspended microchannel resonator (SMR) is capable of measuring individual particle masses with femtogram resolution. The high sensitivity of the SMR resonance frequency to changes in particle position in the SMR channel is employed to determine the electrophoretic mobility of discrete particles in an applied electric field. When an oscillating electric field is applied to the suspended microchannel, the transient resonance frequency shift corresponding to a particle transit can be analyzed to extract both the buoyant mass and electrophoretic mobility of each particle. These parameters, together with the mean particle density, can be used to compute the size, absolute mass, and surface charge of discrete particles.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.