Patents by Inventor Philip Duke Edwards

Philip Duke Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
    Patent number: 5736535
    Abstract: The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: April 7, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Robert Bernstein, Philip Duke Edwards, Andrew Shaw, Ashokkumar Bhikkappa Shenvi, Royston Martin Thomas, Chris Allan Veale, Peter Warner, Donald John Wolanin
  • Peptide derivatives
    Patent number: 5726158
    Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 10, 1998
    Assignee: Zeneca Inc.
    Inventors: Philip Duke Edwards, John Anthony Schwartz, Mark Morris Stein, Diane Amy Trainor, Richard Alan Wildonger