Abstract: Hydrophilic auristatin compounds are described, including Drug-Linker compounds, Ligand-Drug Conjugate compounds, methods of use, and preparations thereof.

Abstract: A system for managing an infrastructure includes extraction engine is in communication with a managed infrastructure that includes physical hardware. A signalizer engine includes one or more of an NMF engine (Non-negative matrix factorization), a k-means clustering engine (a method of vector quantization), and a topology proximity engine. The signalizer engine determines one or more common characteristics of events and produces clusters of events relating to the failure or errors in the infrastructure. The signalizer engine uses graph coordinates and optionally a subset of attributes assigned to each event to generate one or more clusters to bring together events whose characteristics are similar. One or more interactive displays provide a collaborative interface coupled to the extraction and the signalizer engine with a collaborative interface (UI) for decomposing events from the infrastructure.

Abstract: A system is provided for managing a managed infrastructure that has physical hardware components. A signalizer engine is coupled to the managed infrastructure. The signalizer engine includes a central processor and a main memory. In response to input from the managed infrastructure, the central processor and the main memory use graph coordinates to determine hop proximity of a source of an event. Clusters of events are then produced relating to one or more failures or errors in the physical elements of the managed infrastructure. Each event being is converted to words to group the events into the clusters that relate to a failure or an actionable problem in the physical hardware components to produce an output. A compare and merge engine is coupled to the signalizer engine to receive the output. In response to the output, the system executes physical corrections to the physical hardware of the managed infrastructure.

Abstract: THIS invention relates to a method of disposing of residues from the comminution and processing of ores. The method includes the steps of classifying the processing residues into a water permeable sand fraction and a tailings fraction and depositing the tailings fraction and the sand fraction to form a multilayer structure contained by at least one containment wall (14) with the sand fraction forming continuous channels (12) through the tailings fraction (10) to allow water contained in the tailings and sand to flow by gravity, through the sand channels, to water discharge points (16), and recovering the water (18) from the water discharge points.

Abstract: A system texecutes automatic attribute inference and includes: a processor; a memory coupled to the memory; a first engine that executes automatic attribute inference; an extraction engine in communication with a managed infrastructure and the first engine, the extraction engine configured to receive managed infrastructure data; and a signaliser engine that includes one or more of an NMF engine, a k-means clustering engine and a topology proximity engine, the signaliser engine inputting a list of devices and a list a connections between components or nodes in the managed infrastructure, the signaliser engine determining one or more common characteristics and produces one or more dusters of events.

Abstract: A user interface system is provided. At least one engine is provided to receive message data from managed infrastructure that includes managed infrastructure physical hardware that supports the flow and processing of information, determine common characteristics of events and produce clusters of events relating to the failure of errors in the managed infrastructure. Membership in a cluster indicates a common factor of the events that is a failure or an actionable problem in the physical hardware managed infrastructure directed to supporting the flow and processing of information. One or more situations is created that is a collection of one or more events or alerts representative of the actionable problem in the managed infrastructure. A situation room is coupled to or includes a dashboard display computer system and a data system, the display computer system configured to generate a dashboard display configured to display situations from the clustered events.

Abstract: THIS invention relates to a method of disposing of residues from the comminution and processing of ores. The method includes the steps of classifying the processing residues into a water permeable sand fraction and a tailings fraction and depositing the tailings fraction and the sand fraction to form a multilayer structure contained by at least one containment wall (14) with the sand fraction forming continuous channels (12) through the tailings fraction (10) to allow water contained in the tailings and sand to flow by gravity, through the sand channels, to water discharge points (16), and recovering the water (18) from the water discharge points.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: THIS invention relates to a method of disposing of residues from the comminution and processing of ores. The method includes the steps of classifying the processing residues into a water permeable sand fraction and a tailings fraction and depositing the tailings fraction and the sand fraction to form a multilayer structure contained by at least one containment wall (14) with the sand fraction forming continuous channels (12) through the tailings fraction (10) to allow water contained in the tailings and sand to flow by gravity, through the sand channels, to water discharge points (16), and recovering the water (18) from the water discharge points.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: An oil and gas well shaped charge perforator capable of providing an exothermic reaction after detonation is provided, comprising a housing (2), a high explosive (3), and a reactive liner (6) where the high explosive is positioned between the reactive liner and the housing. The reactive liner (6) is produced from a reactive composition which is capable of sustaining an exothermic reaction during the formation of the cutting jet. The composition is a pressed i.e. compacted particulate composition comprising at least two metals, wherein one of the metals is present as spherical particulate, and the other metal is present as a non-spherical particulate. There may also be at least one further metal, which is not capable of an exothermic reaction with the reactive composition, present in an amount greater than 10% w/w of the liner. To aid consolidation a binder may also be added.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.

Abstract: A method is provided for dynamically adding customized advertisements with media content on digital media storage devices. A user may provide identification data to an automated machine or salesperson selling the media content at a retail location. Based upon the identification of the user, advertisements may be selected to be added to the media content. The selection of advertisements may be based upon previous transaction data, the genre of the media content, or characteristics identified for the user. Users may also select to change the quantity of advertisements to view based upon fees paid by the user for the media content. The user may pay additional fees to view less advertisements and the user may pay fewer fees and have more advertisements included with the media content.

Abstract: Some embodiments are directed to a shaped charge liner including an apex end and a base end and defining a main liner axis that passes through the apex and base ends, the liner being rotationally symmetric about the main liner axis wherein the liner has discrete rotational symmetry about the main liner axis.