Abstract: Derivatives of 9-deazaguanine of the formula I: are prepared by reacting an aldehyde or ketone of the formula II: with a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula: The pyrrole is reacted with a compound represented by the formula R3OC(O)N?C(Z)NHC(O)OR3 or a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C1-C4 alkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid.

Abstract: Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound or a derivative of carbamimidoic acid to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

Abstract: T-cell inhibition proliferation in a mammalian host by administering effective amounts of 2′-deoxyguanosine and/or prodrugs thereof; and certain PNP inhibitors.

Abstract: Compounds represented by the formula: 1

Abstract: A feeder for transferring ammunition from a magazine to the loading assem of an elevationally rotatable gun includes a first chute and a second chute. The first chute is pivotally mounted about the magazine. The second chute is articulated between the first chute and the loading assembly. The chutes are sized to provide an internal passage for the ammunition. An endless transfer chain can circulate along an interior path from the magazine through the chutes to drive the ammunition therethrough. This endless transfer chain returns from the interior path to the magazine along a return path. Linkage coupled to the endless transfer chain along its return path can draw it inwardly as the chutes unfold.