Patents by Inventor Philip E. Pfeffer

Philip E. Pfeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 1-.alpha.- and 1-.beta.-glucose esters by stereoselective acylation of metalated 2,3,4,6,-tetra-O-benzyl-D-glucopyranose
    Patent number: 4107425
    Abstract: Anomerically pure 1-.alpha.- and 1-.beta.-esters of 2,3,4,6-Tetra-O-benzyl-D-glucopyranose have been prepared in high yield by controlling the stereochemistry of 1-O-acylation of appropriately protected D-glucose. 2,3,4,6-tetra-O-benzyl-D-glucopyranose is metalated with n-butyllithium in either tetrahydrofuran or anhydrous benzene and the metalated product acylated with an appropriate alkyl, alkenyl, or aryl acid chloride. Hydrogenation of the acyl glucopyranose, when derived from a saturated acid chloride, yields the appropriate 1-.alpha.- or 1-.beta.-D-glucose ester. Reaction in tetrahydrofuran produces the .alpha.-anomer while reaction in anhydrous benzene produces the .beta.-anomer.
    Type: Grant
    Filed: February 15, 1977
    Date of Patent: August 15, 1978
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Philip E. Pfeffer, Gordon G. Moore
  • Process for the preparation of aldehydes
    Patent number: 3963784
    Abstract: Aldehydes are prepared by metalating an aliphatic carboxylic acid with lithium diisopropylamide in a mixed solvent system of tetrahydrofuran-hexane-hexamethylphosphoramide to form a dianion of the acid, reacting the dianion in the mixed solvent system with ethyl formate and decarboxylating the resulting alpha-aldehyde acid salt.
    Type: Grant
    Filed: December 19, 1973
    Date of Patent: June 15, 1976
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Philip E. Pfeffer, Leonard S. Silbert