Patents by Inventor Philip En Hou Wong

Philip En Hou Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Re-trafficking of herg reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes
    Patent number: 9797883
    Abstract: The present invention relates to generating hiPSC-derived cardiomyocytes and embryoid bodies that recapitulate the disease phenotype of Long QT Syndrome and their use in developing pharmacological treatments thereof. The present invention also includes the use of a compound which inhibits the ubiquitin-proteasome pathway for the preparation of a medicament for the prophylaxis or treatment of a disease associated with prolonged ventricular repolarization (cardiac arrhythmia) caused by one or more mutations in the amino acid sequence of the hERG potassium channel.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 24, 2017
    Assignee: Singapore Health Services Pte Ltd
    Inventors: Winston Se Ngie Shim, Ashish Mehta, Chrishan Julian Alles Ramachandra, Philip En Hou Wong
  • RE-TRAFFICKING OF HERG REVERSES LONG QT SYNDROME 2 PHENOTYPE IN HUMAN IPS-DERIVED CARDIOMYOCYTES
    Publication number: 20160033481
    Abstract: The present invention relates to generating hiPSC-derived cardiomyocytes and embryoid bodies that recapitulate the disease phenotype of Long QT Syndrome and their use in developing pharmacological treatments thereof. The present invention also includes the use of a compound which inhibits the ubiquitin-proteasome pathway for the preparation of a medicament for the prophylaxis or treatment of a disease associated with prolonged ventricular repolarization (cardiac arrhythmia) caused by one or more mutations in the amino acid sequence of the hERG potassium channel.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Inventors: Winston Se Ngie SHIM, Ashish MEHTA, Chrishan Julian Alles RAMACHANDRA, Philip En Hou WONG
  • INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED CARDIOMYOCYTE-LIKE CELLS AND USES THEREOF
    Publication number: 20140363841
    Abstract: The present invention relates to a method for screening an agent as a drug candidate using induced pluripotent stem cell-derived cardiomyocyte-like cells (iPSC-CMs). The method is useful for screening cardiovascular agents and/or agents affecting cardiac function. The method is also useful for assessing the cardiotoxicity of agents. The present invention also relates to a method for predicting risk of and/or predisposition to cardiac arrhythmia in a subject.
    Type: Application
    Filed: January 21, 2013
    Publication date: December 11, 2014
    Applicant: SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Winston Se Ngie Shim, Ashish Mehta, Philip En Hou Wong, Reginald Kay Choon Liew
  • Methods and compositions for culturing cardiomyocyte-like cells
    Patent number: 8513011
    Abstract: The present invention provides cardiomyocyte-like cells that have been cultured from populations of bone marrow cells. The culture method includes the use of defined media that are free of agents such a 5-azacytidine. The cardiomyocyte-like cells can be engrafted to heart tissue to repair damage resulting from an ischaemic episode.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: August 20, 2013
    Assignee: Biotech Research Ventures Pte Limited
    Inventors: Winston Se Ngie Shim, Philip En Hou Wong