Patent number: 4463013
Abstract: Conditions of inappropriate hyperhydration in warm blooded animals can be treated with an essentially water only diuretic drug compound selected from the group ##STR1## wherein m, n, p, A, E, R, R.sub.1, R.sub.2, X, Y and Z are as defined in the specification, e.g., trans-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]dec-8 -yl]benzeneacetamide, or a pharmaceutically acceptable salt thereof, ##STR2## wherein R, R.sub.1, R.sub.2, R.sub.3, P, Q, X and Y are as defined in the specification, e.g., 3,4-dichloro-N-[[8-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]-dec-8-yl]methyl]be nzeneacetamide, or a pharmaceutically acceptable salt thereof, or ##STR3## where R, R.sup.1, R.sup.2, X and Y are as defined in the specification, e.g., trans-(1)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] acetamide,or ##STR4## wherein p, n, q, X, Y, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, E, R.sub.5, R.sub.6 are as defined in the specification,or ##STR5## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.
Type:
Grant
Filed:
August 18, 1982
Date of Patent:
July 31, 1984
Assignee:
The Upjohn Company
Inventors:
Robert J. Collins, Lester J. Kaplan, James H. Ludens, Philip F. Von Voigtlander