Patents by Inventor Philip G. Collins
Philip G. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10787704Abstract: The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.Type: GrantFiled: May 11, 2016Date of Patent: September 29, 2020Assignees: ILLUMINA, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kevin L Gunderson, Jingwei Bai, Cheng-Yao Chen, Jeffrey G Mandell, Sergio Peisajovich, Philip G Collins, Gregory A Weiss, Boyan Boyanov
-
Publication number: 20180155773Abstract: The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.Type: ApplicationFiled: May 11, 2016Publication date: June 7, 2018Inventors: Kevin L Gunderson, Jingwei Bai, Cheng-Yao Chen, Jeffrey G Mandell, Sergio Peisajovich, Philip G Collins, Gregory A Weiss, Boyan Boyanov
-
Publication number: 20180051316Abstract: The invention provides methods and compositions for detecting a change in a nucleic acid polymerase conformation involving contacting a nucleic acid polymerase non-covalently attached to a single walled carbon nanotube (SWNT) with a first nucleotide or first nucleotide analog and a template and detecting the conformationally changed nucleic acid polymerase by measuring a first electrical conductance change in the SWNT between the nucleic acid polymerase and the conformationally changed nucleic acid polymerase. The method is useful for sequencing of polynucleotides.Type: ApplicationFiled: December 17, 2015Publication date: February 22, 2018Inventors: Philip G. Collins, Gregory A. Weiss, Yongki Choi, Tivoli Olsen
-
Patent number: 9164053Abstract: A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule having the first functional group non-covalently functionalized with a sidewall of the single-walled carbon nanotube. A single sensitizing molecule having at least one functional group is functionalized with the second functional group of the at least one linker molecule.Type: GrantFiled: September 25, 2012Date of Patent: October 20, 2015Assignee: The Regents of the University of CaliforniaInventors: Philip G. Collins, Gregory A. Weiss, Yongki Choi, Issa S. Moody
-
Patent number: 8900517Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.Type: GrantFiled: November 9, 2007Date of Patent: December 2, 2014Assignee: Nanomix, Inc.Inventors: Jean-Christophe P. Gabriel, Philip G. Collins, George Gruner, Keith Bradley
-
Patent number: 8637374Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: February 8, 2012Date of Patent: January 28, 2014Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Publication number: 20120142158Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: ApplicationFiled: February 8, 2012Publication date: June 7, 2012Inventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Patent number: 8138491Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: August 20, 2009Date of Patent: March 20, 2012Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Patent number: 7897960Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: August 20, 2009Date of Patent: March 1, 2011Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Publication number: 20110003698Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.Type: ApplicationFiled: November 9, 2007Publication date: January 6, 2011Applicant: NANOMIX, INC.Inventors: Jean-Christophe P. Gabriel, Philip G. Collins, Keith Bradley, George Gruner
-
Publication number: 20100001260Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: ApplicationFiled: August 20, 2009Publication date: January 7, 2010Inventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Patent number: 7635856Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: August 7, 2007Date of Patent: December 22, 2009Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Publication number: 20090309092Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: ApplicationFiled: August 20, 2009Publication date: December 17, 2009Inventors: JOERG APPENZELLER, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Patent number: 7575933Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.Type: GrantFiled: May 27, 2005Date of Patent: August 18, 2009Assignee: Nanomix, Inc.Inventors: Jean-Christophe P. Gabriel, Philip G. Collins, Keith Bradley, George Gruner
-
Publication number: 20090165533Abstract: A nanostructure sensing device includes a substrate, a nanotube disposed over the substrate, and at least two conductive elements electrically connected to the nanotube. A electric current on the order of about 10 ?A, or greater, is passed through the conductive elements and the nanotube. As a result, the nanotube heats up relative to the substrate. In the alternative, some other method may be used to heat the nanotube. When operated as a sensor with a heated nanotube, the sensor's response and/or recovery time may be markedly improved.Type: ApplicationFiled: October 3, 2008Publication date: July 2, 2009Applicant: NANOMIX, INC.Inventors: Tzong-Ru Han, Alexander Star, Philip G. Collins, Jean-Christophe P. Gabriel, George Gruner, Keith Bradley
-
Patent number: 7312095Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.Type: GrantFiled: March 15, 2002Date of Patent: December 25, 2007Assignee: Nanomix, Inc.Inventors: Jean-Christophe P. Gabriel, Philip G. Collins, Keith Bradley, George Gruner
-
Patent number: 7253065Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: October 1, 2004Date of Patent: August 7, 2007Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Philip G. Collins, Richard Martel, Hon-Sum Philip Wong
-
Patent number: 6905655Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifiying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.Type: GrantFiled: March 14, 2003Date of Patent: June 14, 2005Assignee: Nanomix, Inc.Inventors: Jean-Christophe P. Gabriel, Philip G. Collins, Keith Bradley, George Gruner
-
Patent number: 6894359Abstract: Nanostructure sensing devices for detecting an analyte are described. The devices include nanostructures connected to conductive elements, all on a substrate. Contact regions adjacent to points of contact between the nanostructures and the conductive elements are given special treatment. The proportion of nanostructure surface area within contact regions can be maximized to effect sensing at very low analyte concentrations. The contact regions can be passivated in an effort to prevent interaction between the environment and the contact regions for sensing at higher analyte concentrations and for reducing cross-sensing. Both contact regions and at least some portion of the nanostructures can be covered with a material that is at least partially permeable to the analyte of interest and impermeable to some other species to tune selectivity and sensitivity of the nanostructure sensing device.Type: GrantFiled: October 26, 2002Date of Patent: May 17, 2005Assignee: Nanomix, Inc.Inventors: Keith Bradley, Philip G. Collins, Jean-Christophe P. Gabriel, George Gruner, Alexander Star
-
Patent number: 6891227Abstract: A self-aligned carbon-nanotube field effect transistor semiconductor device comprises a carbon-nanotube deposited on a substrate, a source and a drain formed at a first end and a second end of the carbon-nanotube, respectively, and a gate formed substantially over a portion of the carbon-nanotube, separated from the carbon-nanotube by a dielectric film.Type: GrantFiled: March 20, 2002Date of Patent: May 10, 2005Assignee: International Business Machines CorporationInventors: Joerg Appenzeller, Phaedon Avouris, Kevin K. Chan, Richard Martel, Hon-Sum Philip Wong, Philip G. Collins