Patents by Inventor Philip G. HUMPHREYS

Philip G. HUMPHREYS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives as bromodomain inhibitors
    Patent number: 11053212
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 6, 2021
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
    Publication number: 20200039953
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Application
    Filed: August 22, 2019
    Publication date: February 6, 2020
    Inventors: Rino Antonio BIT, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • Benzimidazole derivatives as bromodomain inhibitors
    Patent number: 10442786
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • Tetrahydroquinoline derivatives as bromodomain inhibitors
    Patent number: 10059699
    Abstract: The present invention relates to specific novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy as bromodomain inhibitors.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: August 28, 2018
    Assignee: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Stephen John Atkinson, David Jonathan Hirst, Philip G. Humphreys, Matthew J. Lindon, Alexander G. Preston, Jonathan Thomas Seal, Christopher Roland Wellaway
  • BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
    Publication number: 20180044317
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Application
    Filed: March 17, 2016
    Publication date: February 15, 2018
    Inventors: Rino Antonio BIT, John Alexander BROWN, Philip G HUMPHREYS, Katherine Louise JONES
  • TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS
    Publication number: 20170298047
    Abstract: The present invention relates to specific novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy as bromodomain inhibitors.
    Type: Application
    Filed: September 9, 2015
    Publication date: October 19, 2017
    Inventors: Stephen John ATKINSON, David Jonathan HIRST, Philip G. HUMPHREYS, Matthew J. LINDON, Alexander G. PRESTON, Jonathan Thomas SEAL, Christopher Roland WELLAWAY