Abstract: RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds.

Abstract: The present invention relates to compositions, formulations, and methods for treating drug-induced ILF/IPF disorders by administration of a UPase inhibitor, with or without supplemental uridine, a uridine prodrug or a uridine mimetic to a subject in need thereof. Candidate drugs for the treatment include bleomycin and analogs, methotrexate and analogs, and amiodarone and analogs.

Abstract: A system can include a satisfication detection server to receive from a network-enabled device questionnaire responses corresponding to an online questionnaire. The satisfication detection server can determine for each questionnaire response a probability that the questionnaire response represent satisficing. The satisfication detection server can also output a data file that includes results of the determining. A satisfication detection database can store the data file.

Abstract: Response data relating to a plurality of responses to a survey is received. The survey comprises a plurality of questions. The response data for each of the plurality of responses comprises a plurality of answers to at least a subset of the plurality of questions. A questionnaire response model is created using the response data. It is then determined, for each questionnaire response, a respective probability that the respective questionnaire response represents satisficing, such that where the respective probability exceeds a threshold, the respective questionnaire response is identified as an outlier, and where the respective probability does not exceed the threshold, the respective questionnaire response is identified as an inlier. A representation of each questionnaire response is output, each respective representation reflecting the likelihood that the respective response to which the respective representation represents satisficing.

Abstract: Response data relating to a plurality of responses to a survey is received. The survey comprises a plurality of questions. The response data for each of the plurality of responses comprises a plurality of answers to at least a subset of the plurality of questions. A questionnaire response model is created using the response data. It is then determined, for each questionnaire response, a respective probability that the respective questionnaire response represents satisficing, such that where the respective probability exceeds a threshold, the respective questionnaire response is identified as an outlier, and where the respective probability does not exceed the threshold, the respective questionnaire response is identified as an inlier. A representation of each questionnaire response is output, each respective representation reflecting the likelihood that the respective response to which the respective representation represents satisficing.

Abstract: Pyridazine derivatives of the formula: ##STR1## wherein R.sup.1 represents a fluorine, chlorine, bromine or iodine atom or an alkyl, alkoxy, alkylthio, alkylsulphonyl, nitro, trifluoromethyl, cyano, alkoxycarbonyl, carboxy, aminocarbonyl, amino, monoalkylamino or dialkylamino group, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a hydrogen, fluorine, chlorine or bromine atom or an alkyl, methoxy, ethoxy or hydroxy group, or R.sup.2 and R.sup.3 together represent an oxygen atom or a hydroxyimino group, R.sup.4 represents a hydrogen atom or an alkyl group and n represents zero or an integer from 1 to 5 inclusive, are new compounds useful as herbicides.