Abstract: A vehicle coordination system is provided for coordinating the trajectories of vehicles on a road network. The vehicle coordination system comprises a plurality of vehicles each having respective vehicle position tracking assemblies that are in communication with respective vehicle communication systems for transmitting vehicle state messages including positions of the vehicles. A task assignment allocator is provided that is arranged to generate task assignments for each of the plurality of vehicles, including destinations in the road network for the vehicles. A vehicle coordination assembly is in communication with the vehicle communication systems via a data network for receiving the vehicle state messages.

Abstract: A vehicle coordination system is provided for coordinating the trajectories of vehicles on a road network. The vehicle coordination system comprises a plurality of vehicles each having respective vehicle position tracking assemblies that are in communication with respective vehicle communication systems for transmitting vehicle state messages including positions of the vehicles. A task assignment allocator is provided that is arranged to generate task assignments for each of the plurality of vehicles, including destinations in the road network for the vehicles. A vehicle coordination assembly is in communication with the vehicle communication systems via a data network for receiving the vehicle state messages.

Abstract: The present invention relates to compositions and methods for eye and contact lens care. More particularly, the invention relates to ophthalmic compositions which contain at least one bioflavonoid component for ocular care, preserving ophthalmic solutions and/or disinfecting contact lenses.

Abstract: A foldable ladder for providing access to an opening including: a first motorized drive mechanism for moving a cover for the opening between a closed position and an open position; a second motorized drive mechanism coupled to a plurality of foldable ladder portions for moving the ladder portions between a folded configuration and an unfolded configuration; such that, in moving the cover between the closed and an open position, the first motorized drive mechanism triggers the second motorized drive mechanism to move the ladder portions between the folded configuration and unfolded configuration.

Abstract: A foldable ladder for providing access to an opening including: a first motorized drive mechanism for moving a cover for the opening between a closed position and an open position; a second motorized drive mechanism coupled to a plurality of foldable ladder portions for moving the ladder portions between a folded configuration and an unfolded configuration; such that, in moving the cover between the closed and an open position, the first motorized drive mechanism triggers the second motorized drive mechanism to move the ladder portions between the folded configuration and unfolded configuration.

Abstract: There is provided inter alia a germicidal aqueous formulation, suitable for use in the eye, which has a pH of from 4.0 to 6.5 and which comprises 4.0 to 7.5% w/w of povidone-iodine and a viscosity increasing agent, the formulation buffered with a buffer concentration of 25 mM to 75 mM.

Abstract: The present invention relates to compositions and methods for eye and contact lens care. More particularly, the invention relates to ophthalmic compositions which contain at least one bioflavonoid component for ocular care, preserving ophthalmic solutions and/or disinfecting contact lenses.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

Abstract: Headgear for a patient interface includes at least one headgear strap and an indicator provided to the at least one headgear strap structured to indicate attainment of a desired adjustment setting of the headgear in response to headgear tension applied to the at least one headgear strap.

Abstract: An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

Abstract: A patient interface includes a sealing arrangement adapted to provide an effective seal with the patient's nose, an inlet conduit arrangement adapted to deliver breathable gas to the sealing arrangement, and a cover that substantially encloses the sealing arrangement and/or the inlet conduit arrangement.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceuical compositions are also disclosed.

Abstract: Components of a CPAP or other patient ventilation apparatus have a remotely-readable identification tag encoded with component identification data. The flow generator controller 40 is programmed to receive data derived from the identification tag from a tag reader, and to adapt functions of the flow controller to coordinate with the component.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

Abstract: A method to stereospecifically prepare a steroidal sapogenin or a derivative thereof by reducing a 3-keto,5?-H steroidal sapogenin with a hindered organoborane or an organo-aluminium hydride. A 3?-hydroxy,5?-H steroidal sapogenin or derivative thereof may be prepared by reducing the 3-keto,5?-H steroidal sapogenin using as reducing agent a relatively highly hindered organoborane reagent or by SN 2 inversion of a 3?-hydroxy,5?-H steroidal sapogenin or derivative thereof. The organo-aluminium hydride may be used to prepare a 3?,5?-H steroidal sapogenin or derivative thereof. The invention provides a convenient route to useful steroidal sapogenins such as sarsasapogenin, episarsasapogenin, smilagenin, epismilagenin and esters thereof, from readily available or easily preparable starting materials (e.g. diosgenone, preparable from diosgenin).

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.