Patents by Inventor Philip H. Bradley

Philip H. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE COMPOSITIONS AND METHODS OF USE THEREOF FOR DISRUPTING TEAD INTERACTIONS
    Publication number: 20230151068
    Abstract: Described herein are peptides and variants and mutants thereof capable of interacting with TEAD, disrupting the HIPPO pathway, or modulating the activity or function of TEAD interactions in a cell. Pharmaceutical compositions and uses of peptides, as well as methods of designing and manufacturing such peptides, to treat cancer, tumor, or any other disease/condition associated with a dysregulated HIPPO pathway or uncontrolled cell growth are also described herein.
    Type: Application
    Filed: July 26, 2022
    Publication date: May 18, 2023
    Inventors: James M. Olson, Zachary Crook, Philip H. Bradley
  • Peptide compositions and methods of use thereof for disrupting TEAD interactions
    Patent number: 11548923
    Abstract: Described herein are peptides and variants and mutants thereof capable of interacting with TEAD, disrupting the HIPPO pathway, or modulating the activity or function of TEAD interactions in a cell. Pharmaceutical compositions and uses of peptides, as well as methods of designing and manufacturing such peptides, to treat cancer, tumor, or any other disease/condition associated with a dysregulated HIPPO pathway or uncontrolled cell growth are also described herein.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 10, 2023
    Assignee: FRED HUTCHINSON CANCER CENTER
    Inventors: James M. Olson, Zachary Crook, Philip H. Bradley
  • PEPTIDE COMPOSITIONS AND METHODS OF USE THEREOF FOR DISRUPTING TEAD INTERACTIONS
    Publication number: 20190345211
    Abstract: Described herein are peptides and variants and mutants thereof capable of interacting with TEAD, disrupting the HIPPO pathway, or modulating the activity or function of TEAD interactions in a cell. Pharmaceutical compositions and uses of peptides, as well as methods of designing and manufacturing such peptides, to treat cancer, tumor, or any other disease/condition associated with a dysregulated HIPPO pathway or uncontrolled cell growth are also described herein.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 14, 2019
    Inventors: James M. Olson, Zachary Crook, Philip H. Bradley
  • ENGINEERED TAL EFFECTOR PROTEINS WITH ENHANCED DNA TARGETING CAPACITY
    Publication number: 20140186957
    Abstract: The present invention provides compositions and methods for DNA targeting using TAL effectors and TAL effector based proteins, including but not limited to targeted gene regulation and targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector or a TAL effector binding domain in combination with other domains, including but not limited to a cleavage domain. The TAL effector binding domain includes modifications that increase activity of the same and also remove the constraints that the DNA target sequence be preceded by a thymine.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 3, 2014
    Applicants: Fred Hutchinson Cancer Research Center, Iowa State University Research Foundation, Inc.
    Inventors: Adam Joseph Bogdanove, Barry Leonard Stoddard, Philip H. Bradley, Erin Lynn Doyle