Patents by Inventor Philip Henry Coelho
Philip Henry Coelho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7182107Abstract: A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.Type: GrantFiled: December 15, 2003Date of Patent: February 27, 2007Assignee: ThermoGenesis Corp.Inventors: Eric Sommer, Philip Henry Coelho, Phil Kingsley
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Patent number: 7169547Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.Type: GrantFiled: May 15, 2001Date of Patent: January 30, 2007Assignee: New York Blood Center, Inc.Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
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Patent number: 7056722Abstract: A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.Type: GrantFiled: November 10, 2000Date of Patent: June 6, 2006Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Phil Kingsley, Jim Brausch, James H. Godsey, Gail Rock
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Patent number: 6808675Abstract: A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed with their larger planar surfaces in contact with each other.Type: GrantFiled: September 28, 2000Date of Patent: October 26, 2004Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Pablo Rubinstein
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Publication number: 20040140012Abstract: A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.Type: ApplicationFiled: December 15, 2003Publication date: July 22, 2004Inventors: Eric Sommer, Philip Henry Coelho, Phil Kingsley
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Patent number: 6679300Abstract: A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.Type: GrantFiled: January 14, 2002Date of Patent: January 20, 2004Assignee: ThermoGenesis Corp.Inventors: Eric Sommer, Philip Henry Coelho, Phil Kingsley
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Patent number: 6491678Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.Type: GrantFiled: May 18, 1999Date of Patent: December 10, 2002Assignee: New York Blood Center, Inc.Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
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Patent number: 6472162Abstract: A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.Type: GrantFiled: June 4, 1999Date of Patent: October 29, 2002Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Phil Kingsley, Jim Brausch, James H. Godsey, Gail Rock, Trista K. Madsen, Sona B. Frausto
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Publication number: 20010034513Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.Type: ApplicationFiled: May 15, 2001Publication date: October 25, 2001Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
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Patent number: 6274090Abstract: A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.Type: GrantFiled: August 5, 1998Date of Patent: August 14, 2001Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Phil Kingsley, Jim Brausch, James H. Godsey, Gail Rock
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Patent number: 6232115Abstract: A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.Type: GrantFiled: November 25, 1997Date of Patent: May 15, 2001Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Pablo Rubinstein
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Patent number: 6146124Abstract: A mold is disclosed for forming a freezable and thawable bag of uniform thickness, especially useful for cryopreservation of thermolabile substances. The mold features one or more recessed planar surfaces, including radiused peripheral walls about the recesses, a planar top surface, and means for conforming a blank sheet to the mold. Two mold halves combine to form a completed bag. The mold halves may be complimentary.Type: GrantFiled: June 25, 1996Date of Patent: November 14, 2000Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Pablo Rubinstein
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Patent number: 6123696Abstract: A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.Type: GrantFiled: July 16, 1998Date of Patent: September 26, 2000Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Pablo Rubinstein
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Patent number: 5964095Abstract: A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.Type: GrantFiled: June 16, 1997Date of Patent: October 12, 1999Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Terry Wolf, Pablo Rubinstein
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Patent number: 5928214Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.Type: GrantFiled: August 3, 1998Date of Patent: July 27, 1999Assignee: New York Blood Center, Inc.Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
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Patent number: 5789147Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.Type: GrantFiled: December 5, 1994Date of Patent: August 4, 1998Assignee: New York Blood Center, Inc.Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
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Patent number: 5638686Abstract: A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.Type: GrantFiled: February 23, 1995Date of Patent: June 17, 1997Assignee: ThermoGenesis CorporationInventors: Philip Henry Coelho, Terry Wolf, Pablo Rubinstein
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Patent number: D408527Type: GrantFiled: February 2, 1998Date of Patent: April 20, 1999Assignee: ThermoGenesis Corp.Inventors: Philip Henry Coelho, Brian G. Malone, Pete Menke, Loren Stirling, John Gard