Patents by Inventor Philip Heppner

Philip Heppner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for imidazonaphthyridines
    Publication number: 20080091010
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 17, 2008
    Applicant: Graceway Pharmaceuticals, LLC
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines
    Publication number: 20080015184
    Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 14, 2005
    Publication date: January 17, 2008
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Tushar Kshirsagar, George Griesgraber, Sarah Johannessen, Azim Celebi, Philip Heppner, Gregory Lundquist Jr., David Amos, Bernhard ZImmermann, Scott Langer
  • Isoxazole, Dihydroisoxazole, And Oxadiazole Substituted Imidazo Ring Compounds And Method
    Publication number: 20070287725
    Abstract: Imidazo ring compounds, (e.g. imidazo[4,5-c]pyridine, imidazo[4,5-c]quinoline, 6,7,8,9-tetrahydro imidazo[4,5-c]quinoline, and imidazo[4,5-c]naphthyridine compounds) having an isoxazole, dihydroisoxazole, or oxadiazole substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: December 13, 2007
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: William Miser, Joan Moseman, Tushar Kshirsagar, Philip Heppner
  • Substituted Imidazo Ring Systems and Methods
    Publication number: 20070259881
    Abstract: Imidazo ring systems, which include, for example, imidazopyridine, imidazoquinoline, 6,7,8,9-tetrahydroimidazoquinoline, imidazonaphthyridine, and 6,7,8,9-tetrahydroimidazonaphthyridine compounds substituted at the 1-position and/or the 2-position, pharmaceutical compositions containing these compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: November 8, 2007
    Inventors: Joseph Dellaria, Tushar Kshirsagar, Shri Niwas, William Moser, Joan Moseman, Kyle Lindstrom, Azim Celebi, John Gerster, Philip Heppner, Joshua Wurst
  • Aryl substituted imidazonaphthyridines
    Publication number: 20070219228
    Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: September 20, 2007
    Inventors: Shri Niwas, Bryon Merrill, Philip Heppner, Tushar Kshirsagar, Gregory Lundquist, David Amos, Kyle Lindstrom
  • Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
    Publication number: 20070208052
    Abstract: Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: September 6, 2007
    Inventors: Ryan Prince, Michael Rice, Joshua Wurst, Bryon Merrill, Tushar Kshirsagar, Philip Heppner
  • Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
    Publication number: 20070167476
    Abstract: Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 19, 2007
    Inventors: Tushar Kshirsagar, George Griesgraber, Azim Celebi, Philip Heppner
  • Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
    Publication number: 20070099901
    Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: November 24, 2004
    Publication date: May 3, 2007
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Larry Krepski, Joseph Dellaria, Daniel Duffy, David Amos, Bernhard Zimmermann, David Squire, Gregory Marszalek, Philip Heppner, Tushar Kshirsagar
  • Oxime substituted imidazoquinolines
    Publication number: 20070066639
    Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 22, 2007
    Inventors: Tushar Kshirsagar, David Amos, Joseph Dellaria Jr, Philip Heppner, Scott Langer, Bernhard Zimmermann
  • Alkoxy substituted imidazoquinolines
    Publication number: 20070060754
    Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Application
    Filed: October 1, 2004
    Publication date: March 15, 2007
    Inventors: Kyle Lindstrom, Bryon Merrill, Chad Haraldson, Michael Rice, Tushar Kshirsagar, Philip Heppner, Joshua Wurst, Shri Niwas, Sarah Johannessen
  • ETHER SUBSTITUTED IMIDAZOPYRIDINES
    Publication number: 20060252792
    Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: July 24, 2006
    Publication date: November 9, 2006
    Inventors: Joseph Dellaria, Kyle Lindstrom, Luke Dressel, Philip Heppner, John Jacobsen, Joan Moseman, William Moser, Matthew Radmer, Doris Stoermer
  • INTERMEDIATES FOR IMIDAZONAPHTHYRIDINES
    Publication number: 20060128674
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Application
    Filed: February 13, 2006
    Publication date: June 15, 2006
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • ARYL SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20060111387
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Application
    Filed: January 13, 2006
    Publication date: May 25, 2006
    Inventors: David Hays, Tushar Kshirsagar, Philip Heppner, Bryon Merrill, Michael Danielson, John Gerster, Chad Haraldson, Sarah Johannessen, Maureen Kavanagh, Kyle Lindstrom, Michael Rice, David Squire, Sarah Strong, Joshua Wurst
  • Pyrazolopyridines and analogs thereof
    Publication number: 20060100229
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: April 1, 2005
    Publication date: May 11, 2006
    Inventors: David Hays, Michael Danielson, John Gerster, Shri Niwas, Ryan Prince, Tushar Kshirsagar, Philip Heppner, William Moser, Joan Moseman, Matthew Radmer, Maureen Kavanagh, Sarah Strong, Jason Bonk
  • IMIDAZONAPHTHYRIDINES
    Publication number: 20050288320
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: July 25, 2005
    Publication date: December 29, 2005
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • Amide substituted imidazopyridines
    Publication number: 20050282854
    Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: August 10, 2005
    Publication date: December 22, 2005
    Inventors: Philip Heppner, Kyle Lindstrom, Bryon Merrill
  • Sulfonamido ether substituted imidazoquinolines
    Publication number: 20050148620
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill, Ralph Roberts, Ai-Ping Wei
  • Sulfonamido ether substituted imidazoquinolines
    Publication number: 20050148619
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill, Ralph Roberts, Ai-Ping Wei
  • Amido ether substituted imidazoquinolines
    Publication number: 20050143413
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: June 30, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill
  • Imidazonaphthyridines
    Publication number: 20050107421
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: December 3, 2004
    Publication date: May 19, 2005
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalck, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice