Patents by Inventor Philip Huffstetler
Philip Huffstetler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200054251Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more boronic acid-drug conjugates configured to release one or more drugs in the presence of a degradative species, wherein the one or more boronic acid-drug conjugates reduce deterioration of the analyte indicator.Type: ApplicationFiled: August 20, 2019Publication date: February 20, 2020Applicant: Senseonics, IncorporatedInventors: Venkata Velvadapu, Philip Huffstetler
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Patent number: 10551316Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: GrantFiled: November 5, 2018Date of Patent: February 4, 2020Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Patent number: 10435517Abstract: A hydrogel is dried by a critical point drying technique. The hydrogel may include indicator molecules embedded therein and may be part of a hydrogel-based device, such as, for example, an analyte sensor.Type: GrantFiled: April 6, 2018Date of Patent: October 8, 2019Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Aneta Modzelewska
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Patent number: 10352858Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: GrantFiled: January 12, 2018Date of Patent: July 16, 2019Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Publication number: 20190159708Abstract: An analyte sensor may include a sensor housing and an analyte indicator element embedded within and/or covering at least a portion of the sensor housing. The analyte indicator element may include a porous base having an interior surface and an exterior surface. The analyte indicator may include a catalytically active material disposed on at least one of the interior and exterior surfaces of the porous base, in which the catalytically active material catalyzes the degradation of reactive oxygen species. The analyte indicator may include a polymer unit polymerized onto or out of the porous base and an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit.Type: ApplicationFiled: November 28, 2018Publication date: May 30, 2019Applicant: Senseonics, IncorporatedInventors: Mark Mortellaro, Philip Huffstetler, Tina HyunJung Kim, Sanat Mohanty
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Publication number: 20190079009Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: ApplicationFiled: November 5, 2018Publication date: March 14, 2019Applicant: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Publication number: 20190015021Abstract: A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.Type: ApplicationFiled: September 17, 2018Publication date: January 17, 2019Applicant: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Publication number: 20180353113Abstract: A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The sensor may include one or more of a first coating on an inner surface of the membrane, a second coating on an outer surface of the membrane, and a layer on the outside of the indicator element. One or more of the first coating, second coating, and layer may reduce deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS). The one or more coatings on the membrane may increase the light blocking capability of the membrane, which may improve the accuracy of the sensor.Type: ApplicationFiled: June 15, 2018Publication date: December 13, 2018Applicant: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst, Masika Hinds, Mark Mortellaro, Abhi Chavan, Bryan Hays
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Patent number: 10119911Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: GrantFiled: May 26, 2017Date of Patent: November 6, 2018Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Publication number: 20180303387Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.Type: ApplicationFiled: April 19, 2018Publication date: October 25, 2018Applicant: Senseonics, IncorporatedInventors: Andrew Dehennis, Mark Mortellaro, Abhi Chavan, Venkata Velvadapu, Philip Huffstetler, Tina HyunJung Kim
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Patent number: 10080514Abstract: A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.Type: GrantFiled: November 14, 2014Date of Patent: September 25, 2018Assignee: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Patent number: 10064573Abstract: A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.Type: GrantFiled: August 29, 2016Date of Patent: September 4, 2018Assignee: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Publication number: 20180223050Abstract: A hydrogel is dried by a critical point drying technique. The hydrogel may include indicator molecules embedded therein and may be part of a hydrogel-based device, such as, for example, an analyte sensor.Type: ApplicationFiled: April 6, 2018Publication date: August 9, 2018Applicant: Senseonics, IncorporatedInventors: Philip Huffstetler, Aneta Modzelewska
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Publication number: 20180220940Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the analyte indicator, a membrane covering at least a portion of the analyte indicator, and/or one or more drug eluting polymer matrices, which may be external to or within the sensor housing.Type: ApplicationFiled: April 2, 2018Publication date: August 9, 2018Applicant: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Publication number: 20180177396Abstract: Methods, sensors, and systems that prevent or reduce data loss when more than one external sensor transceiver is used with a sensor. A sensor may receive a transceiver identification (ID) of an external transceiver conveyed from the external transceiver and determine whether the received transceiver ID is a new transceiver ID. If sensor determines the received transceiver ID to be a new transceiver ID, the sensor may store the received transceiver ID in a nonvolatile storage medium of the sensor and convey, using the sensor, measurement information stored in the nonvolatile storage medium to the external transceiver.Type: ApplicationFiled: February 26, 2018Publication date: June 28, 2018Applicant: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Publication number: 20180136128Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: ApplicationFiled: January 12, 2018Publication date: May 17, 2018Applicant: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Patent number: 9963556Abstract: A hydrogel is dried by a critical point drying technique. The hydrogel may include indicator molecules embedded therein and may be part of a hydrogel-based device, such as, for example, an analyte sensor.Type: GrantFiled: September 18, 2014Date of Patent: May 8, 2018Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Aneta Modzelewska
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Patent number: 9931068Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the analyte indicator, a membrane covering at least a portion of the analyte indicator, and/or one or more drug eluting polymer matrices, which may be external to or within the sensor housing.Type: GrantFiled: August 21, 2014Date of Patent: April 3, 2018Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst
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Patent number: 9901250Abstract: Methods, sensors, and systems that prevent or reduce data loss when more than one external sensor transceiver is used with a sensor. A sensor may receive a transceiver identification (ID) of an external transceiver conveyed from the external transceiver and determine whether the received transceiver ID is a new transceiver ID. If sensor determines the received transceiver ID to be a new transceiver ID, the sensor may store the received transceiver ID in a nonvolatile storage medium of the sensor and convey, using the sensor, measurement information stored in the nonvolatile storage medium to the external transceiver.Type: GrantFiled: October 9, 2014Date of Patent: February 27, 2018Assignee: Senseonics, IncorporatedInventors: Jeremy Emken, Philip Huffstetler, Todd Whitehurst
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Patent number: 9891169Abstract: An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.Type: GrantFiled: May 26, 2017Date of Patent: February 13, 2018Assignee: Senseonics, IncorporatedInventors: Philip Huffstetler, Jeremy Emken, Todd Whitehurst