Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: A method, an apparatus and a computer readable-medium for monitoring a continuous steel casting process where molten steel is poured from a ladle into a tundish to be transferred through an exit nozzle into a mold. The method includes obtaining a critical superheat temperature value for the molten steel; measuring temperature values of the molten steel over a time period; determining superheat temperature values corresponding to the measured temperature values by comparing the measured temperature values with a liquidus temperature of the molten steel; and predicting a forecast time instance when the critical superheat temperature value is reached.

Abstract: The present invention relates to a method for monitoring a continuous steel casting process where molten steel is poured from a ladle into a tundish to be transferred through an exit nozzle into a mold, comprising the steps: obtaining (1010) a critical superheat temperature value for the molten steel; measuring (1020) temperature values of the molten steel over a time period; determining (1030) superheat temperature values corresponding to the measured temperature values by comparing the measured temperature values with a liquidus temperature of the molten steel; and predicting (1040) a forecast time instance when the critical superheat temperature value is reached. The invention also relates to an apparatus and to a computer-readable medium.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: Compounds of formula (I) wherein the substituents are defined as in claim 1, are suitable for use as herbicides. Also claimed is the intermediate (II) wherein R1 is chloro, R2 is hydrogen and XA is methylsulfonate, three processes for the preparation of compounds of formula (Ih) wherein m is 1 or 2, and the other substituents are defined as in claim 1, and a process for the preparation of compounds of the formula (IVa) wherein XB is a halogen atom, and the substitutents are defined as in claim 1.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: In a communications arrangement, a copper wire pair arrangement traditionally used to provide a plain old telephone service (POTS) is also used to provide an asymmetric digital subscriber line (ADSL) service. To that end, a patch cord in accordance with the invention is used to re-arrange communications connections in a terminal where both POTS channel unit and ADSL channel unit are deployed. Advantageously, the combined service is efficiently realized by such a re-arrangement, with the existing POTS virtually uninterrupted.

Abstract: Disclosed is a network interface unit which includes customer bridges and an array of circuits such as maintenance termination units (MTUs). The MTUs are provided on printed circuit boards, each including a male and female connector. Each board is inserted in between posts in the unit housing so that the female connectors plug into a mother board at the bottom. Jack wires are plugged into the male connectors and extend to the customer bridge portion of the unit.

Abstract: A combined work station and phototherapy unit in which the fixture containing the light source is mounted on a vertical support to be placed on the base of the open area for work to be performed, the fixture being at an angle, preferably in the range of 30.degree.-60.degree., so that the user will not be staring directly into the light from the fixture. There will be light both impringing upon the eyes of the user for photobiological effect and also light will be directed to the work area.

Abstract: A method is disclosed to provide optimal or near-optimal vertical stacking of seismic records within the constraints imposed by real time data acquisition procedures. This method is characterized by forming output seismic traces which are a sum of prorated input traces, such proration being performed by application of smoothly varying weight functions derived from estimated signal and noise power levels within each input trace. Each weight function is computed using frequency domain filtering techniques to obtain a well behaved bandlimited time series for each function. The method also includes a procedure for clipping grossly large noise spikes in the input traces before the stacking procedure is performed, thereby guarding the weight calculation procedure against aliasing effects induced by such spikes.

Abstract: Apparatus inserted in series in a transmission line connecting subscriber equipment with a telephone central office and which apparatus is responsive to test signals from the central office to determine whether a fault is located on the office side or the subscriber side of the apparatus is enclosed in a housing. A plurality of leads from the apparatus project through an opening in the housing and the leads are connected to electrical terminals of a connector block. The housing in one embodiment has two spaced apart ribs which are lodged between tabs of fanning strips, located on both sides of the terminals. One of the ribs has an end with a width larger than the rest of the rib so that end projects inward from the fanning strip and prevents accidental dislodging of the housing from the connector block. In a second embodiment, the housing is supported by at least one tab from one fanning strip.

Abstract: Method and apparatus for digitally deriving arrays from seismic data. Indentical parallel processing elements connected between common input/output buses are each preselected to derive different pluralities of arrays. Array specifications defining the arrays are downloaded into the processing elements. A scan sample set of spatially distributed seismic receivers is periodically generated and placed on the input bus. Each processing element, in response to array specifications, captures and stores all receiver output signals in the scan required to derive its respective arrays, derives its assigned arrays, and delivers resultant array samples to the output bus. Double input and output buffering in the processing elements is provided whereby receiver capture, array derivation, and outputing processes occur simultaneously in each processing element.

Abstract: A system for roadside collection of municipal refuse includes a rotatable lift platform mounted on a refuse sink and which is adapted to invert a portable household refuse container to dump its contents. The container has a pair of horizontal locking bars on one face. The upper bar fits into a fixed hook on the rotatable platform. The lower bar is positively locked to the frame by means of a hydraulic piston which moves a lower hook into locking position upon the initiation of the frame rotation and moves such hook out of the locking position upon completion of the dumping operation.

Abstract: Disclosed herein is circuitry for producing a signal proportional to the rate of recurrence of a periodic input signal applied to the circuitry. When an input pulse is received a timing circuit is energized to charge a capacitor to a predetermined level. The capacitor is then discharged through a resistance circuit having resistance portions which are electronically switched in and out of the circuit so that the discharge, rate of the capacitor defines the desired rate function. Then, upon commencement of a subsequent pulse a sample and hold circuit is actuated to sample the discharge level of the capacitor to provide an accurate indication of the pulse rate.