Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: A method, an apparatus and a computer readable-medium for monitoring a continuous steel casting process where molten steel is poured from a ladle into a tundish to be transferred through an exit nozzle into a mold. The method includes obtaining a critical superheat temperature value for the molten steel; measuring temperature values of the molten steel over a time period; determining superheat temperature values corresponding to the measured temperature values by comparing the measured temperature values with a liquidus temperature of the molten steel; and predicting a forecast time instance when the critical superheat temperature value is reached.

Abstract: An underwater acoustic receiver apparatus (100) comprises an acoustic reflector (102, 104, 106, 108) and an acoustic device (110, 114, 116, 118) aimed at the acoustic reflector (102, 104, 106, 108). The acoustic reflector (102, 104, 106, 108) is disposed at a predetermined distance and orientation relative to the acoustic device (110, 114, 116, 118).

Abstract: The present invention relates to a method for monitoring a continuous steel casting process where molten steel is poured from a ladle into a tundish to be transferred through an exit nozzle into a mold, comprising the steps: obtaining (1010) a critical superheat temperature value for the molten steel; measuring (1020) temperature values of the molten steel over a time period; determining (1030) superheat temperature values corresponding to the measured temperature values by comparing the measured temperature values with a liquidus temperature of the molten steel; and predicting (1040) a forecast time instance when the critical superheat temperature value is reached. The invention also relates to an apparatus and to a computer-readable medium.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.

Abstract: Compounds of formula (I) wherein the substituents are defined as in claim 1, are suitable for use as herbicides. Also claimed is the intermediate (II) wherein R1 is chloro, R2 is hydrogen and XA is methylsulfonate, three processes for the preparation of compounds of formula (Ih) wherein m is 1 or 2, and the other substituents are defined as in claim 1, and a process for the preparation of compounds of the formula (IVa) wherein XB is a halogen atom, and the substitutents are defined as in claim 1.

Abstract: A method of making a nanoparticulate based lubricant is disclosed. The method includes providing solid lubricant material with particles having a size less than or equal to about 500 nanometers, and treating the particles to create composite nanoparticles. The composite nanoparticles includes the solid lubricant material and at least a second material.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Abstract: Presented is a trailer incorporating a device that allows the detachable coupling of the ball coupler and safety chains of a trailer for remote storage of these items, while incorporating a security feature that allows only the original ball coupler and safety chains to be connected. This deters the unauthorized towing or theft of the trailer.

Abstract: Presented is a device for use in detachably coupling two load bearing members which allows the transmission of linear, torsion and bending moment forces, while incorporating a security feature that allows only properly matched sets of members to be connected.

Abstract: In a communications arrangement, a copper wire pair arrangement traditionally used to provide a plain old telephone service (POTS) is also used to provide an asymmetric digital subscriber line (ADSL) service. To that end, a patch cord in accordance with the invention is used to re-arrange communications connections in a terminal where both POTS channel unit and ADSL channel unit are deployed. Advantageously, the combined service is efficiently realized by such a re-arrangement, with the existing POTS virtually uninterrupted.

Abstract: Disclosed is a network interface unit which includes customer bridges and an array of circuits such as maintenance termination units (MTUs). The MTUs are provided on printed circuit boards, each including a male and female connector. Each board is inserted in between posts in the unit housing so that the female connectors plug into a mother board at the bottom. Jack wires are plugged into the male connectors and extend to the customer bridge portion of the unit.

Abstract: A combined work station and phototherapy unit in which the fixture containing the light source is mounted on a vertical support to be placed on the base of the open area for work to be performed, the fixture being at an angle, preferably in the range of 30.degree.-60.degree., so that the user will not be staring directly into the light from the fixture. There will be light both impringing upon the eyes of the user for photobiological effect and also light will be directed to the work area.