Patents by Inventor Philip J. Brown
Philip J. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115304Abstract: Disclosed herein are surgical tool systems and methods of using such to install a fixator in a biological tissue. The systems are capable of accurately measuring torque and rotational velocity and providing real time feedback to a user during surgery.Type: ApplicationFiled: December 11, 2023Publication date: April 11, 2024Inventors: Philip J. Brown, Andrea Morgan Rich, Aaron Ross Van Gorkom
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Patent number: 11871975Abstract: Disclosed herein are surgical tool systems and methods of using such to install a fixator in a biological tissue. The systems are capable of accurately measuring torque and rotational velocity and providing real time feedback to a user during surgery.Type: GrantFiled: October 5, 2017Date of Patent: January 16, 2024Assignee: Wake Forest University Health SciencesInventors: Philip J. Brown, Andrea Morgan Rich, Aaron Ross Van Gorkom
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Publication number: 20200100842Abstract: The present disclosure relates to systems and methods for carrying out image-guided medical procedures. In some aspects and embodiments, the disclosure provides systems and methods for improving the accuracy of such procedures, especially where multiple tools are used to carry out the procedure.Type: ApplicationFiled: October 2, 2019Publication date: April 2, 2020Inventors: Scotty A. Chung, Philip J. Brown
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Publication number: 20200038084Abstract: Disclosed herein are surgical tool systems and methods of using such to install a fixator in a biological tissue. The systems are capable of accurately measuring torque and rotational velocity and providing real time feedback to a user during surgery.Type: ApplicationFiled: October 5, 2017Publication date: February 6, 2020Inventors: Philip J. Brown, Andrea Morgan Rich, Aaron Ross Van Gorkom
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Publication number: 20200041430Abstract: The present invention provides devices, systems, and methods for using them to monitor therapeutic cooling of blood perfused tissues or organs such as the brain. In one embodiment, the invention comprises a device for evaluating tissue cooling comprising a container that contains a polymer-fluid matrix having a thermal cooling property that is substantially similar to a tissue or organ such as a human brain. In another embodiment, the invention comprises a system for evaluating tissue cooling comprising: (a) a device for evaluating tissue cooling as described above and (b) a warm loop. In another embodiment, the invention comprises a method for evaluating a technique for cooling a tissue or organ comprising (a) providing a device comprising a container that contains a polymer-fluid matrix having a thermal cooling property that is substantially similar to a tissue or organ such as human brain, and (b) perfusing the polymer-fluid matrix with a fluid.Type: ApplicationFiled: October 6, 2017Publication date: February 6, 2020Inventors: F. Scott Gayzik, Ryan D.M. Packett, Philip J. Brown, Gautam Popli, Megan Fritz
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Patent number: 10441550Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.Type: GrantFiled: February 18, 2016Date of Patent: October 15, 2019Assignees: BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITYInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 10398847Abstract: An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a discrete audible sound or “click,” or preferably both, for every unit of medication aspirated or injected to or from an individual syringe. Hence, there is no need to look at the syringe, or bring it to the eye level, during use thereof. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included. Syringe plungers useful for combining with a syringe body to produce such an incremental syringe are also described.Type: GrantFiled: December 11, 2015Date of Patent: September 3, 2019Assignee: Wake Forrest University Health SciencesInventors: Majid Mirzazadeh, Philip J. Brown, Kenneth W. Russell
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Patent number: 10328032Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: GrantFiled: June 2, 2014Date of Patent: June 25, 2019Assignees: BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITYInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20190053922Abstract: Non-migrating stent devices and methods for using the devices are provided for treatment of visceral anastomosis strictures or vascular ostium high grade stenosis. For example, placement of a non-migrating stent may be appropriate following a surgical procedure such as hollow visceral anastomosis.Type: ApplicationFiled: February 24, 2017Publication date: February 21, 2019Inventors: Clifford Howard, JR., Philip J. Brown
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Publication number: 20180133422Abstract: Tracheal tube devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a handle holding a cutting member. The mouthpiece can include at least one outwardly projecting substantially rigid short tube. The cutting member may be held in a handle releasably attached to the short tube.Type: ApplicationFiled: June 16, 2015Publication date: May 17, 2018Inventors: Michael A. Olympio, Philip J. Brown
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Publication number: 20160166772Abstract: An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a discrete audible sound or “click,” or preferably both, for every unit of medication aspirated or injected to or from an individual syringe. Hence, there is no need to look at the syringe, or bring it to the eye level, during use thereof. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included. Syringe plungers useful for combining with a syringe body to produce such an incremental syringe are also described.Type: ApplicationFiled: December 11, 2015Publication date: June 16, 2016Inventors: Majid Mirzazadeh, Philip J. Brown, Kenneth W. Russell
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Publication number: 20160158160Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: February 18, 2016Publication date: June 9, 2016Applicants: BioSurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20140271795Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicants: BioSurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 8771582Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: GrantFiled: November 23, 2011Date of Patent: July 8, 2014Assignees: BioScurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20140054828Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: November 23, 2011Publication date: February 27, 2014Inventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 8501644Abstract: Disclosed are fibrous activated materials that can remove and/or deactivate potentially dangerous airborne agents from a gas or air stream. Disclosed materials are multi-layer materials that include a fibrous nonwoven interceptor layer and an active layer immediately adjacent the interceptor layer. The interceptor layer is a fibrous membrane of very low basis weight and defines a relatively low porosity, and the active layer describes geometries, chemistries, etc. that can entrap and/or decontaminate compounds contained in an airstream passing through the material. Disclosed materials can be utilized in forming protective garments, face masks, and the like.Type: GrantFiled: June 2, 2009Date of Patent: August 6, 2013Inventors: Christine W. Cole, Philip J. Brown, Kathryn Stevens, Deborah K. Lickfield
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Patent number: 8389114Abstract: Disclosed is a process for modification of a substrate so as to form an ultrahydrophobic surface on the substrate. Also disclosed are surface-modified substrates that can be formed according to the disclosed processes. The process includes attachment of a multitude of nano- and/or submicron-sized structures to a surface to provide increased surface roughness. In addition, the process includes grafting a hydrophobic material to the surface in order to decrease the surface energy and decrease wettability of the surface. The combination of increase surface roughness and decreased surface energy can provide an ultrahydrophobic surface on the treated substrate.Type: GrantFiled: June 15, 2011Date of Patent: March 5, 2013Assignee: Clemson UniversityInventors: Igor A. Luzinov, Philip J. Brown, Killugudi L. Swaminatha Iyer, Viktor Z. Klep, Bogdan Z. Zdyrko
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Publication number: 20120068384Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: November 23, 2011Publication date: March 22, 2012Inventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20110262709Abstract: Disclosed is a process for modification of a substrate so as to form an ultrahydrophobic surface on the substrate. Also disclosed are surface-modified substrates that can be formed according to the disclosed processes. The process includes attachment of a multitude of nano- and/or submicron-sized structures to a surface to provide increased surface roughness. In addition, the process includes grafting a hydrophobic material to the surface in order to decrease the surface energy and decrease wettability of the surface. The combination of increase surface roughness and decreased surface energy can provide an ultrahydrophobic surface on the treated substrate.Type: ApplicationFiled: June 15, 2011Publication date: October 27, 2011Applicant: CLEMSON UNIVERSITYInventors: Igor A. Luzinov, Philip J. Brown, Killugudi L. Swaminatha Iyer, Viktor Z. Klep, Bogdan V. Zdyrko
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Patent number: 7985451Abstract: A process for modification of a substrate so as to form an ultrahydrophobic surface on the substrate is provided. Surface-modified substrates that can be formed according to the disclosed processes are also provided. The process includes attachment of a multitude of nano- and/or submicron-sized structures to a surface to provide increased surface roughness. In addition, the process includes grafting a hydrophobic material to the surface in order to decrease the surface energy and decrease wettability of the surface. The combination of increased surface roughness and decreased surface energy can provide an ultrahydrophobic surface on the treated substrate.Type: GrantFiled: March 31, 2006Date of Patent: July 26, 2011Assignee: Clemson UniversityInventors: Igor A. Luzinov, Philip J. Brown, Killugudi L. Swaminatha Iyer, Viktor Z. Klep, Bogdan V. Zdyrko