Patents by Inventor Philip J. Burke

Philip J. Burke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLS1 inhibitors for treating disease
    Patent number: 11958849
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: April 16, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Timothy Heffernan, Matthew M. Hamilton, Zhijun Kang, Michael J. Soth, Jason P. Burke, Kang Le, Christopher Lawrence Carroll, Wylie S. Palmer, Richard Lewis, Timothy McAfoos, Barbara Czako, Gang Liu, Jay Theroff, Zachary Herrera, Anne Yau
  • Mechanically actuated tape head cleaner having debris removal vacuum
    Patent number: 6212036
    Abstract: A cartridge for cleaning read/write heads and associated tape path in a magnetic tape system includes a brush arranged to loosen debris, and an impeller driven by a tape drive mechanism to create a vacuum within the cartridge housing to facilitate capture of the loosened debris within a removable filter. In one embodiment, the brush is attached to a wiper arm driven by either the same or a second tape drive mechanism in the tape system. The wiper arm can be driven in a direction orthogonal to the direction of tape movement to allow efficient cleaning of magnetic heads having bleed slots or gutters which extend orthogonal to the tape path. In addition, the wiper arm can be made of electrically conductive material, and the cartridge can include a conductive base plate arranged to provide a ground path between the brush and a ground potential in the tape system, thereby safely dissipating any buildup of static electricity.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: April 3, 2001
    Assignee: Storage Technology Corporation
    Inventors: Christian Allen Todd, Philip J. Burke
  • Prodrugs for antibody directed enzyme prodrug therapy
    Patent number: 5587161
    Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT).
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: December 24, 1996
    Assignees: Zeneca Limited, Cancer Research Campaign Technology Limited
    Inventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer
  • Chemical compounds
    Patent number: 5405990
    Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: April 11, 1995
    Assignees: Zeneca Limited, Cancer Research Campaign Technology Limited
    Inventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer