Abstract: The invention provides for carrying out 3-dimensional similarity searching by comparing a probe molecule to each member of a 3-dimensional database. The probe molecule is overlapped with each member of a database of molecules and then the database molecule is rotated and translates until its similarity with the probe molecule is maximized. The system can contain ten different scoring functions to rate the similarity between the two molecules. Each function employs different molecular features when scoring a particular comparison. Some methods are based on the relative shape of the two molecules, and some are based on the overlap of key atoms such as oxygen, nitrogen, sulfur, and/or halogens.

Abstract: This invention discloses a system and method useful in moving labware between laboratory devices, such as liquid handlers, readers, washers, dispensers, sealers, incubators, microarrayers and labeling devices, such a bar code labelers, to aid in automation of laboratory tasks and assay procedures. Work cells addressing particular laboratory tasks comprise modular components such as stack links, track links, arm links and laboratory devices, such as washers or plate readers. Based upon the required flow of labware movement, the individual modular components are selected and interconnected to create a high-speed work cell. The work cells are easy to configure and setup and permit configuration on available bench top space or within other small spaces, such as laboratory fume hoods. All mechanical and electrical connections between the module components of the work cell are self-contained within the system.

Abstract: A dried sample processor employs a loader which reads unique identification data from a carrier web, and supplies such data to a computerized controller. The carrier web is then brought to a punch arrangement which punches a specimen sample therefrom and deposits same into a well of a microtiter array. The microtiter array and the wells therein are moved into registration with the punch hole of the punch unit under the control of the computerized controller. The correlated carrier web identification data and the address of the well in the microtiter plate are displayed as graphical information on a computer monitor, and made available to other components of a computerized laboratory.

Abstract: A loader arrangement is provided with a first conveyor for delivering an article to a first station, and a second conveyor for delivering a container to a respective first station. A gripper engages the article at the first station of the first conveyor, and a linear actuator, which is coupled to the gripper, moves the gripper along a first linear axis. Once the article has been engaged by the gripper, a rotator moves the linear actuator rotatively so that it parallels a second linear axis which is angularly displaced first the first linear axis. The gripper then is moved along the second linear axis, which is arranged to intersect with the first station of the second conveyor. A tilting arrangement is provided at one or both of the first stations for moving the container and/or the article arcuately to achieve an orthogonal orientation with respect to the second linear axis.