Patents by Inventor Philip J. Kranzusch

Philip J. Kranzusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR ALTERING CYCLIC ADP-RIBOSE SECONDARY MESSENGER SIGNALLING
    Publication number: 20250049835
    Abstract: Methods of treating a disease or disorder associated with a down or up-regulation of an immune response of a subject are disclosed. The methods comprising administering to the subject a therapeutically effective amount of any one or more of the molecule 1?-2? glycosyl cyclic adenosine diphosphate ribose (1?-2? gcADPR), 1?-3? gcADPR or Tad1 protein.
    Type: Application
    Filed: October 25, 2024
    Publication date: February 13, 2025
    Applicants: Yeda Research and Development Co. Ltd., Dana-Farber Cancer Institute, Inc.
    Inventors: Rotem SOREK, Gil AMITAI, Azita LEAVITT, Erez YIRMIYA, Philip J. KRANZUSCH, Allen LU, Samuel J. HOBBS
  • Human CGAS-DNA complex and encoded protein
    Patent number: 12146168
    Abstract: The present invention is based, in part, on the discovery of the human-specific regulatory control of cGAS and the structure of the active human cGAS-DNA complex, as well as compositions comprising the modified hcGAS polypeptide, hcGAS-DNA complex, hcGAS-DNA-ATP complex, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides and complexes.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 19, 2024
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Philip J. Kranzusch, John J. Mekalanos, Aaron T. Whiteley, Wen Zhou
  • CGAS/DNCV-LIKE NUCLEOTIDYLTRANSFERASES AND USES THEREOF
    Publication number: 20220127586
    Abstract: The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 28, 2022
    Inventors: Aaron Whiteley, Philip J. Kranzusch, John Mekalanos, James Eaglesham
  • STRUCTURE OF THE HUMAN CGAS-DNA COMPLEX AND USES THEREOF
    Publication number: 20210324351
    Abstract: The present invention is based, in part, on the discovery of the human-specific regulatory control of cGAS and the structure of the active human cGAS-DNA complex, as well as compositions comprising the modified hcGAS polypeptide, hcGAS-DNA complex, hcGAS-DNA-ATP complex, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides and complexes.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 21, 2021
    Inventors: Philip J. Kranzusch, John J. Mekalanos, Aaron T. Whiteley, Wen Zhou