Patents by Inventor Philip J. Kranzusch

Philip J. Kranzusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CGAS/DNCV-LIKE NUCLEOTIDYLTRANSFERASES AND USES THEREOF
    Publication number: 20220127586
    Abstract: The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 28, 2022
    Inventors: Aaron Whiteley, Philip J. Kranzusch, John Mekalanos, James Eaglesham
  • STRUCTURE OF THE HUMAN CGAS-DNA COMPLEX AND USES THEREOF
    Publication number: 20210324351
    Abstract: The present invention is based, in part, on the discovery of the human-specific regulatory control of cGAS and the structure of the active human cGAS-DNA complex, as well as compositions comprising the modified hcGAS polypeptide, hcGAS-DNA complex, hcGAS-DNA-ATP complex, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides and complexes.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 21, 2021
    Inventors: Philip J. Kranzusch, John J. Mekalanos, Aaron T. Whiteley, Wen Zhou