Patents by Inventor Philip J. Santangelo

Philip J. Santangelo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240382606
    Abstract: The present disclosure relates to nanoparticle compositions for modifying antigen-specific T cells and uses thereof.
    Type: Application
    Filed: April 20, 2022
    Publication date: November 21, 2024
    Inventors: Gabriel A. Kwong, Shreyas Dahotre, Marielena Gamboa, Philip J. Santangelo, Fang-Yi Su, Daryll Vanover
  • Publication number: 20240342294
    Abstract: Provided herein are branched BAE/BTE-containing polymers useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The polymers form stable compositions and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
    Type: Application
    Filed: June 10, 2024
    Publication date: October 17, 2024
    Applicant: GEORGIA TECH REAEARCH GROUP
    Inventors: M.G. Finn, Philip J. Santangelo, Daryll Vanover, Nicholas Bruno
  • Patent number: 11795456
    Abstract: Compositions and methods for treating or inactivating viruses in a subject in need thereof are provided herein. Exemplary compositions include nucleic acids encoding an RNA-guided endonuclease and a guide RNA that is complementary to a target sequence in a virus. The RNA-guided endonuclease specifically targets viral nucleic acid sequences for destruction and suppression of that virus in a host cell in vitro or in vivo.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: October 24, 2023
    Assignee: Georgia Tech Research Corporation
    Inventors: Swapnil Bawage, Pooja M. Tiwari, Philip J. Santangelo
  • Publication number: 20210315980
    Abstract: The present invention provides a method for treating, and compositions useful for treating, Flavivirus infections in a human by administering to the human an effective amount of mRNA encoding Mus musculus resistant 2?-5? oligoadenylate synthetase 1b (rOas1b), or variants thereof.
    Type: Application
    Filed: August 21, 2019
    Publication date: October 14, 2021
    Inventors: Margo A. Brinton, Joseph C. Madden, Jr., Philip J. Santangelo
  • Publication number: 20210163938
    Abstract: Compositions and methods for treating or inactivating viruses in a subject in need thereof are provided herein. Exemplary compositions include nucleic acids encoding an RNA-guided endonuclease and a guide RNA that is complementary to a target sequence in a virus. The RNA-guided endonuclease specifically targets viral nucleic acid sequences for destruction and suppression of that virus in a host cell in vitro or in vivo.
    Type: Application
    Filed: April 15, 2019
    Publication date: June 3, 2021
    Inventors: Swapnil BAWAGE, Pooja M. TIWARI, Philip J. SANTANGELO
  • Patent number: 8785615
    Abstract: The various embodiments of the present disclosure relate generally to single molecule sensitive probes for detecting RNA, and more particularly to multivalent fluorescent probes for detecting a single molecule of RNA in a cell. The present invention includes a RNA imaging probe comprising: a multivalent core comprising a plurality of attachment sites; a plurality of RNA/DNA chimeric oligonucleotides having a specificity for a target RNA, wherein a RNA/DNA chimeric oligonucleotide is bound to an attachment site of the multivalent core; and a plurality of fluorophores, wherein a fluorophore is bound to the RNA/DNA chimeric oligonucleotide.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: July 22, 2014
    Assignee: Georgia Tech Research Corporation
    Inventor: Philip J. Santangelo
  • Publication number: 20120107798
    Abstract: The various embodiments of the present disclosure relate generally to single molecule sensitive probes for detecting RNA, and more particularly to multivalent fluorescent probes for detecting a single molecule of RNA in a cell. The present invention includes a RNA imaging probe comprising: a multivalent core comprising a plurality of attachment sites; a plurality of RNA/DNA chimeric oligonucleotides having a specificity for a target RNA, wherein a RNA/DNA chimeric oligonucleotide is bound to an attachment site of the multivalent core; and a plurality of fluorophores, wherein a fluorophore is bound to the RNA/DNA chimeric oligonucleotide.
    Type: Application
    Filed: March 25, 2010
    Publication date: May 3, 2012
    Applicant: GEORGIA TECH RESEARCH CORPORATION
    Inventor: Philip J. Santangelo