Abstract: The present invention relates to a microfluidic cartridge (100) for detecting biomolecules in a sample solution, having a detection chamber (140) to which the sample solution is suppliable through a feed channel (124) and from which the analyzed sample solution is drainable through an outlet channel (126), a CMOS-based microchip (142) that comprises a sensor area (144) arranged in the detection chamber (140) and a contact area (146) that is fluid-tightly separated from the detection chamber (140), the sensor area (144) of the microchip (142) including an array of functionalized test sites (130) for electrochemically detecting biomolecules in the sample solution, and each test site (130) in the sensor area (140) being furnished with its own sigma-delta modulator (132) for the analog-to-digital conversion of electrical signals produced at the test sites (130) upon electrochemical detection.