Patents by Inventor Philip Jordan Thomas

Philip Jordan Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein/solubility folding assessed by structural complementation
    Patent number: 7635569
    Abstract: Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying proper and improper protein folding, aberrant processing and/or insolubility. The method relies on the use of two components: a specialized fusion protein and structural complementation. The fusion protein contains sequences from the protein of interest and one portion of a marker protein that, by itself, is not active. A host cell then provides the remainder of the marker protein that serves to “complement” the function of the fused marker protein such that their association restores activity, permitting detection.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 22, 2009
    Assignees: Board of Regents, The University of Texas System, Trustees of Columbia University in the City of New York
    Inventors: Philip Jordan Thomas, John F. Hunt, William Christian Wigley, Rhesa D. Stidham
  • Protein/solubility folding assessed by structural complementation
    Patent number: 7455978
    Abstract: Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying proper and improper protein folding, aberrant processing and/or insolubility. The method relies on the use of two components: a specialized fusion protein and structural complementation. The fusion protein contains sequences from the protein of interest and one portion of a marker protein that, by itself, is not active. A host cell then provides the remainder of the marker protein that serves to “complement” the function of the fused marker protein such that their association restores activity, permitting detection.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: November 25, 2008
    Assignees: The Trustees of Columbia University In The City of New York, Board of Regents, The University of Texas System
    Inventors: Philip Jordan Thomas, John F. Hunt, William Christian Wigley, Rhesa D. Stidham
  • Protein/solubility folding assessed by structural complementation
    Patent number: 6727070
    Abstract: Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying proper and improper protein folding, aberrant processing and/or insolubility. The method relies on the use of two components: a specialized fusion protein and structural complementation. The fusion protein contains sequences from the protein of interest and one portion of a marker protein that, by itself, is not active. A host cell then provides the remainder of the marker protein that serves to “complement” the function of the fused marker protein such that their association restores activity, permitting detection.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: April 27, 2004
    Assignees: The Board of Regents, The University of Texas System, The Trustees of Columbia University in the City of New York
    Inventors: Philip Jordan Thomas, John F. Hunt, William Christian Wigley, Rhesa D. Stidham
  • PROTEIN/SOLUBILITY FOLDING ASSESSED BY STRUCTURAL COMPLEMENTATION
    Publication number: 20040002065
    Abstract: Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying proper and improper protein folding, aberrant processing and/or insolubility. The method relies on the use of two components: a specialized fusion protein and structural complementation. The fusion protein contains sequences from the protein of interest and one portion of a marker protein that, by itself, is not active. A host cell then provides the remainder of the marker protein that serves to “complement” the function of the fused marker protein such that their association restores activity, permitting detection.
    Type: Application
    Filed: January 31, 2001
    Publication date: January 1, 2004
    Inventors: Philip Jordan Thomas, John F. Hunt, William Christian Wigley, Rhesa D. Stidham