Patents by Inventor Philip Knowles
Philip Knowles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6610740Abstract: A nutritional, cosmetic or pharmaceutical formulation comprising esters of polyethylene glycol in which the polyethylene glycol chain is terminated at one end by a polyunsaturated fatty acyl group, preferably C18-C22 and at the other end by a C1-C4 alkyl group, preferably a methyl group.Type: GrantFiled: November 12, 1998Date of Patent: August 26, 2003Assignee: Scotia Holdings PLCInventors: Paul Andrew Wakefield, Philip Knowles, Mehar Singh Manku, David Frederick Horrobin
-
Patent number: 6555700Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.Type: GrantFiled: January 28, 1998Date of Patent: April 29, 2003Assignee: Scotia Holdings plcInventors: David Frederick Horrobin, Mehar Manku, Austin McMordie, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield
-
Patent number: 6245811Abstract: Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R2 is as R1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C1-C4 alkyl group.Type: GrantFiled: August 18, 1999Date of Patent: June 12, 2001Assignee: Scotia Holdings PLCInventors: David Frederick Horrobin, Mehar Manku, Austin McMordie, Philip Knowles, Peter Redden, Andrea Pitt
-
Patent number: 6177470Abstract: Optimum conditions for prostaglandin synthesis are provided by internally administering an ascorbic-6-acid ester of gamma-linolenic acid or an ascorbic-6-acid ester of dihomo-gamma-linolenic acid.Type: GrantFiled: March 2, 1998Date of Patent: January 23, 2001Assignee: Scotia Holdings PLCInventors: David F Horrobin, Philip Knowles, Mehar S Manku
-
Patent number: 6015821Abstract: Compounds, compositions, and methods of use as a pharmaceutical, where the compounds have structure (I), where B is --C(.dbd.O)-- or --CH.sub.2 --O--, C is a direct bond or is a diol residue, a hydroxy-substituted carboxylic acid residue, or a dicarboxylic acid residue, and D is a fatty acid residue or a fatty alcohol residue, where the acid residues or alcohol residues for ester linkages with the corresponding alcohols or acids.Type: GrantFiled: March 3, 1998Date of Patent: January 18, 2000Inventors: David Frederick Horrobin, Mehar Manku, Austin McMordie, Philip Knowles, Peter Redden, Andrea Pitt
-
Patent number: 5990164Abstract: An N-alkylpolyhydroxyamine salt of an n-6 or n-3 essential fatty acid (EFA) that is beyond the 6-desaturation step, or of any polyunsaturated fatty acid, other than those belonging to the n-6 and n-3 series, having 16 to 26 carbon atoms and up to six double bonds, the double bonds being in the cis or trans configuration, the salt being formed with the fatty acid either as such or in the form of a covalent derivative, through the carboxyl group, of a bifunctional compound itself having a free acid function.Type: GrantFiled: March 17, 1998Date of Patent: November 23, 1999Assignee: Scotia Holdings PLCInventors: David F. Horrobin, Philip Knowles, Mehar Manku, John C. Stewart
-
Patent number: 5866703Abstract: Triglycerides with at least two different acids chosen from 6-desaturated essential fatty acids and oleic acid, useful in nutrition and in medicine.Type: GrantFiled: October 16, 1995Date of Patent: February 2, 1999Assignee: Scotia Holdings PLCInventors: David F. Horrobin, Austin McMordie, Mehar Singh Manku, Philip Knowles
-
Patent number: 5847000Abstract: Ascorbyl-GLA or Ascorbyl-DGLA in medicaments for treatment of asthma and other disorders.Type: GrantFiled: March 28, 1997Date of Patent: December 8, 1998Assignee: Scotia Holdings PLCInventors: David F. Horrobin, Philip Knowles, Mehar S Manku
-
Patent number: 5670540Abstract: A triglyceride for use in therapy or as a nutritional supplement, or a composition containing a triglyceride, wherein the triglyceride comprises a fatty acid selected from gamma-linolenic acid and the n-6 EPAs naturally derived therefrom and stearidonic acid and the n-3 EFAs naturally derived therefrom, forming a triple ester with glycerol or alternatively forming a double ester in which the other esterifying acide is a single residue of linoleic acid, with the proviso that the di-gammalinolenoyl-mono-linoleoyl glyceride if selected is used as a preparation containing more than 20% by weight thereof.Type: GrantFiled: May 15, 1995Date of Patent: September 23, 1997Assignee: Scotia Holdings PLCInventors: David F. Horrobin, Philip Knowles, Mehar Singh Manku, Austin McMordie
-
Patent number: 5603959Abstract: An NSAID in the form of a compound with an essential fatty acid or essential fatty acid alcohol, particularly an NSAID as listed in categories 1 to 9 herein. Further, a method of preparation of a medicament for the treatment including prophylatic treatment of rheumatoid arthritis, osteoarthritis and related disorders; dysmenorrhoea; dementias, including Alzheimer's disease; or any other inflammatory or other conditions specified herein, wherein the said NSAID is used.Type: GrantFiled: February 22, 1995Date of Patent: February 18, 1997Assignee: Scotia Holdings PlcInventors: David F. Horrobin, Philip Knowles
-
Patent number: 4647569Abstract: Pyridylaminoethene derivatives of the formula: ##STR1## wherein R.sup.1 is pyridyl, unsubstituted or substituted by one or more substituents R.sup.4 selected from halogen, amino, carboxy, cyano nitro, hydroxy, formyl, trifluoromethyl, aryl, aryloxy, arylthio, benzyloxycarbonylamino, sulphamoyl, tetrazol-5-yl, carbamoyl, thiocarbamoyl, arylcarbamoyl, aroyl, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylamino, alkylsulphamoyl, arylalkyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, N-benzyloxycarbonyl-N-alkylamino, or dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl, wherein the alkyl groups may together form a ring, and R.sup.2 and R.sup.3 each represents phenyl, unsubstituted or substituted by one or more substituents R.sup.4 as hereinbefore defined, possess antiarthritic properties.Type: GrantFiled: September 19, 1985Date of Patent: March 3, 1987Assignee: May & Baker LimitedInventors: Raymond F. Collins, Philip Knowles, Libert C. Saunders, Francis J. Tierney, Peter J. Warne
-
Patent number: 4442115Abstract: New tetrazole derivatives of the general formula: ##STR1## [wherein R.sup.1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula:--CR.sup.2 .dbd.NOR.sup.3 II(wherein R.sup.Type: GrantFiled: June 1, 1979Date of Patent: April 10, 1984Assignee: May & Baker LimitedInventors: Christopher A. Ramsden, Philip Knowles, Edward J. Lewis, Edward Lunt, Derek E. Wright
-
Patent number: 4167568Abstract: 8-Azapurin-6-one derivatives of the formula: ##STR1## wherein R.sup.8 represents alkoxy of from 1 to 6 carbon atoms, and R.sup.9 represents cyano, or a group of the formula V, VI, VII, VIII or IX indicated below: ##STR2## wherein R.sup.10, R.sub.13 and R.sup.14 each represents cyano, or alkanoyl or alkoxycarbonyl of from 2 to 6 carbon atoms, R.sup.11 represents hydrogen, cyano, or alkanoyl or alkoxycarbonyl of from 2 to 6 carbon atoms, R.sup.12 represents hydrogen or, when R.sup.11 represents hydrogen, R.sup.12 represents alkyl of from 1 to 6 carbon atoms or alkoxycarbonyl of from 2 to 6 carbon atoms, or the pair of symbols R.sup.11 and R.sup.12 form together an alkylene chain of the formula --(C.sub.q H.sub.2q)-- wherein q is an integer from 3 to 6, R.sup.15 and R.sup.16 each represents hydrogen or alkyl of from 1 to 6 carbon atoms, and Y.sup.Type: GrantFiled: October 20, 1977Date of Patent: September 11, 1979Assignee: May & Baker LimitedInventors: Philip Knowles, Edward Lunt, Stuart M. Marshall, Roger E. Ford
-
Patent number: 4146631Abstract: Benzamide derivatives of the formula:- ##STR1## wherein R.sup.1 represents a fluorine, chlorine or bromine atom, or an alkyl, alkoxy, alkylthio, alkylsulphonyl, alkanoylamino, alkylamino or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), an alkanoyl, alkoxycarbonyl, alkoxycarbonylamino or alkylcarbamoyl group containing from 2 to 6 carbon atoms, or a hydroxy, formyl, nitro, trifluoromethyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl or aroyl group, and n represents an integer 1, 2 or 3, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.Type: GrantFiled: November 3, 1977Date of Patent: March 27, 1979Assignee: May & Baker LimitedInventors: Roger E. Ford, Philip Knowles, Edward Lunt, Stuart M. Marshall, Anthony J. H. Summers
-
Patent number: RE40480Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.Type: GrantFiled: May 1, 1996Date of Patent: September 2, 2008Assignee: Scarista LimitedInventors: Sherri Clarkson, Mehar Manku, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield, Austin McMordie, David B. Horrobin
-
Patent number: RE40546Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.Type: GrantFiled: May 1, 1996Date of Patent: October 21, 2008Assignee: Scarista, Ltd.Inventors: Sherri Clarkson, Mehar Manku, Peter Redden, Paul Wakefield, Paul Bradley, Philip Knowles, Andrea Pitt, Austin McMordie, David Fredrick Horrobin
-
Patent number: RE43632Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.Type: GrantFiled: May 1, 1996Date of Patent: September 4, 2012Assignee: Scarista, Ltd.Inventors: David B. Horrobin, Sherri Clarkson, legal representative, Mehar Manku, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield, Austin McMordie