Patents by Inventor Philip L. Lorenzi

Philip L. Lorenzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC ASPARAGINASES
    Publication number: 20160213759
    Abstract: Provided herein are mutant asparaginase enzymes that lack glutaminase activity. Also provided are methods of treating ASNS-negative cancer cells with a glutaminase-free asparaginase.
    Type: Application
    Filed: September 10, 2014
    Publication date: July 28, 2016
    Inventors: Susan REMPE, David M. ROGERS, Andriy ANISHKIN, Sergei SUKHAREV, Philip L. LORENZI, Wai Kin CHAN, John N. WEINSTEIN
  • Materials and methods directed to asparagine synthetase and asparaginase therapies
    Patent number: 9181552
    Abstract: Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: November 10, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Philip L. Lorenzi, John N. Weinstein, Natasha J. Caplen
  • MATERIALS AND METHODS DIRECTED TO ASPARAGINE SYNTHETASE AND ASPARAGINASE THERAPIES
    Publication number: 20110229984
    Abstract: Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies.
    Type: Application
    Filed: June 2, 2011
    Publication date: September 22, 2011
    Applicant: The USA, as represented by the Secretary, Dep. of Health and Human Services
    Inventors: Philip L. Lorenzi, John N. Weinstein, Natasha J. Caplen
  • Materials and methods directed to asparagine synthetase and asparaginase therapies
    Patent number: 7985548
    Abstract: Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: July 26, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Philip L. Lorenzi, John N. Weinstein, Natasha J. Caplen
  • MATERIALS AND METHODS DIRECTED TO ASPARAGINE SYNTHETASE AND ASPARAGINASE THERAPIES
    Publication number: 20090311233
    Abstract: Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies.
    Type: Application
    Filed: March 2, 2007
    Publication date: December 17, 2009
    Inventors: Philip L. Lorenzi, John N. Weinstein, Natasha J. Caplen