Patents by Inventor Philip L. Loziuk

Philip L. Loziuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for detection and quantification of ?-N-methylamino-L-alanine
    Patent number: 11370812
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 28, 2022
    Assignee: North Carolina State University
    Inventors: David C. Muddiman, Philip L. Loziuk, Joshua G. Pierce, Gavin Williams, Yasamin Moazami
  • COMPOSITIONS AND METHODS FOR DETECTION OF BETA N METHYLAMINO L ALANINE IN CU ZN SUPEROXIDE DISMUTASE 1
    Publication number: 20190241607
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in the Cu/Zn Superoxide Dismutase 1 (SOD1) protein. Further provided are methods for detecting, preventing, or treating amyotrophic lateral sclerosis in a subject using isotopically labeled reagents to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in the Cu/Zn Superoxide Dismutase 1 (50D1) protein. Further provided are isotopically labeled reagents and methods for detecting BMAA in additional proteins from patient samples.
    Type: Application
    Filed: July 31, 2017
    Publication date: August 8, 2019
    Inventors: David C. Muddiman, Philip L. Loziuk, Michael Bereman
  • MATERIALS AND METHODS FOR DETECTION AND QUANTIFICATION OF BETA-N-METHYLAMINO-L-ALANINE
    Publication number: 20190161515
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.
    Type: Application
    Filed: July 31, 2017
    Publication date: May 30, 2019
    Inventors: David C. Muddiman, Philip L. Loziuk, Joshua G. Pierce, Gavin Williams, Yasamin Moazami