Patents by Inventor Philip Leder

Philip Leder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell death protein
    Patent number: 5674734
    Abstract: Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: October 7, 1997
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Philip Leder, Brian Seed, Ben Z. Stanger, Tae-Ho Lee, Emily Kim
  • Detection and isolation of ligands
    Patent number: 5554499
    Abstract: Disclosed is a method of isolating a ligand from a sample, the method including: providing a hybrid molecule including the receptor for the ligand covalently bonded to the first member of a specific binding pair; contacting sample with the hybrid molecule to form an affinity complex between the ligand and the hybrid molecule; and isolating the affinity complex using the second member of the specific binding pair. Also disclosed is a c-kit ligand, nucleic acid encoding such a ligand, and recombinant cells containing such nucleic acid. The c-kit ligand may be used to stimulate hematopoietic cell growth.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: September 10, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, John G. Flanagan
  • Use of the cytokine IP-10 as an anti-tumor agent
    Patent number: 5474981
    Abstract: Methods and therapeutic compositions for treating neoplasms by administration of the polypeptide IP-10, or a suitable DNA vector encoding the polypeptide IP-10.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: December 12, 1995
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, Andrew Luster
  • Cell culture system
    Patent number: 5459058
    Abstract: Disclosed is a method for the culture of higher eukaryotic cells which are dependent for survival on an exogenous factor. The method involves co-culturing the factor-dependent cells with an immortalized eukaryotic cell that has been engineered to secrete the requisite factor.Also disclosed is a cell line of non-stromal cell origin which secretes interleukin-7.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: October 17, 1995
    Assignee: Benjamin Rich
    Inventors: Philip Leder, Benjamin E. Rich
  • Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
    Patent number: 5270197
    Abstract: A homogeneous population of cells having on average (1) a number of cell surface low-affinity heparin-binding growth factor (HBGF) sites per cell less than 20% of the number of such binding sites found on wild-type CHO-K1 cells (ATCC Accession No. CCL61), and at least three times the number of cell surface high-affinity HBGF receptors per cell found on such CHO-K1 cells; and an assay system utilizing such cells.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: December 14, 1993
    Assignees: The Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Avner Yayon, David M. Ornitz, Michael Klagsbrun, Philip Leder
  • Animal model for benign prostatic disease
    Patent number: 5175383
    Abstract: A male transgenic mouse containing germ cells and somatic cells which contain a recombinant gene which is a vertebrate gene in the int-2/FGF family which is capable of promoting benign prostatic hyperplasia or hypertrophy in said transgenic mouse, said gene being introduced into the mouse, or an ancestor of the mouse, at an embryonic stage.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: December 29, 1992
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, William J. Muller
  • Method for providing a cell culture from a transgenic non-human mammal
    Patent number: 5087571
    Abstract: A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: February 11, 1992
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, Timothy A. Stewart
  • DNA encoding IgE receptor alpha-subunit or fragment thereof
    Patent number: 4962035
    Abstract: A cDNA sequence encoding the .alpha.-subunit of human mast cell IgE surface receptor or an IgE binding fragment thereof.
    Type: Grant
    Filed: December 1, 1987
    Date of Patent: October 9, 1990
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, Akira Shimizu, Reuben Siraganian, Philip Benfey
  • Transgenic non-human mammals
    Patent number: 4736866
    Abstract: A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
    Type: Grant
    Filed: June 22, 1984
    Date of Patent: April 12, 1988
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, Timothy A. Stewart
  • Protein from SV40 recombinants
    Patent number: 4599308
    Abstract: An E. Coli plasmid SV40 vector recombinant is cloned to a gene of interest and amplified in bacteria. The SV40 vector-gene of interest can be introduced into eukaryotic cells by transformation or transfection and the gene of interest produces its protein product.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: July 8, 1986
    Inventors: Dean H. Hamer, Marian Kaehler, Philip Leder
  • Detecting rearranged human c-myc DNA fragments associated with oncogenes
    Patent number: 4542096
    Abstract: Rearranged DNA fragments associated with oncogenes are detected by DNA hybridization to a labelled probe comprising DNA fragment subject to rearrangement.
    Type: Grant
    Filed: February 25, 1983
    Date of Patent: September 17, 1985
    Assignee: President and Fellows of Harvard College
    Inventor: Philip Leder