Abstract: A method and kit for determining a nucleic acid is provided, including: providing magnetic nanoparticles and detectable nanoparticles to the sample, wherein the magnetic nanoparticles and detectable nanoparticles respectively contain oligonucleotides attached thereto, and the detectable nanoparticles contain at least one kind of nanoparticles with detectable signals distinct from the others, and the oligonucleotides attached on each kind of the detectable nanoparticles are complementary to a region of one of the nucleic acids in the sample; reacting the magnetic and detectable nanoparticles with the sample; and detecting signals from each kind of the detectable nanoparticles for determining the nucleic acid for each in the sample.

Abstract: A method and kit for determining a nucleic acid is provided, including: providing magnetic nanoparticles and detectable nanoparticles to the sample, wherein the magnetic nanoparticles and detectable nanoparticles respectively contain oligonucleotides attached thereto, and the detectable nanoparticles contain at least one kind of nanoparticles with detectable signals distinct from the others, and the oligonucleotides attached on each kind of the detectable nanoparticles are complementary to a region of one of the nucleic acids in the sample; reacting the magnetic and detectable nanoparticles with the sample; and detecting signals from each kind of the detectable nanoparticles for determining the nucleic acid for each in the sample.

Abstract: Disclosed are Surface Enhanced Resonance Raman Spectroscopy (SERRS) probes and their use in detection methods for bioassays. Further disclosed is signal optimization of surface enhanced resonance Raman probes achieved by chemical modification of the probes. Also disclosed are methods for increasing the Raman cross-section by varying the chemical composition of a linker group linking a signal molecule to a nanoparticle surface. The signal molecules, such as dyes, may be modified with a linker group designed to both enhance the SERRS signal and to couple the signal molecule to the nanoparticle surface.

Abstract: A method and a system for Raman detection are provided. Embodiments of the method include providing a fluid analyte at a signal-enhancing structure including a V-groove for Raman signal enhancement of the analyte. The invention further provides a Raman detection system which includes the above signal-enhancing structure and a Raman spectrometer.

Abstract: Disclosed are Surface Enhanced Resonance Raman Spectroscopy (SERRS) probes and their use in detection methods for bioassays. Further disclosed is signal optimization of surface enhanced resonance Raman probes achieved by chemical modification of the probes. Also disclosed are methods for increasing the Raman cross-section by varying the chemical composition of a linker group linking a signal molecule to a nanoparticle surface. The signal molecules, such as dyes, may be modified with a linker group designed to both enhance the SERRS signal and to couple the signal molecule to the nanoparticle surface.

Abstract: A one-dimensional nanowire and the preparation thereof. The nanowire is self-assembled by at least three building blocks. Each building block comprises a nanoparticle coated with first and second ligands thereon, and the first and second ligands are regionally confined to opposite hemispheres of the nanoparticle. The first ligand is either A or B, and the second ligand is either X or Y; provided that A only reacts with B and X only reacts with Y.