Abstract: Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.

Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A technique for servicing a memory request is disclosed. The technique includes obtaining permissions associated with a source and a destination specified by the memory request, obtaining a first set of address translations for the memory request, and executing operations for a first request, using the first set of address translations.

Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.

Abstract: Systems and methods for generating and using geozones (e.g., merchant-specific isochrones) to rank merchants within a delivery service application. The system can obtain data including a merchant location. The method includes generating a geozone for the respective merchant based on the merchant location and an estimated travel time to various subzones. The method includes storing the geozone for the merchant. The method includes ranking one or more merchants based on their respective geozones and a drop-off location associated with a delivery service request. The method includes facilitating the delivery service. The method includes providing progress updates to a user associated with various progress points of the delivery service.

Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

Abstract: Compositions and methods are provided for inhibiting TGF-?. Trap molecules are provided in which a ligand-binding domain of transforming growth factor-beta receptor type 2 (TGF?RII) is fused to an immunoglobulin Fc domain that contains an N-terminal immunoglobulin hinge region where at least one unpaired cysteine residue of said hinge region is replaced by a serine residue.

Abstract: Self-activating chimeric signaling proteins, and especially chimeric TNF family member ligand-receptor proteins are contemplated. In preferred methods, the chimeric protein comprises an extracellular portion of CD40L that is coupled via a flexible linker to CD40 such that the fusion protein, when expressed in an APC, is capable of folding back on itself and transmits a CD40-mediated signal as if it had been contacted by CD40L located on another cell. Advantageously, cells expressing such chimeric proteins contemporaneously with presentation of an antigen will enhance an immune reaction against the antigen.

Abstract: A computerized interactive learning system includes a display device and a compatible input device. The display device provides work items to a learner. The input device detects input activities from the learner in response to the work item. The system analyzes the input activities at two or more tiered levels of granularity. The display device provides conditional feedback to the learner based on the analysis. The input device and the display device can be incorporated into an integrated touchscreen.

Abstract: Method implementing a generic computer human input device using key event signal coding compliant to the standard protocols so as to expand its application range without losing plug-and-play property. Applications of the present invention include audience response, gaming, legacy system support and cross-platform system integration, for example.

Abstract: System integrating one or more touchscreen devices into a general-purpose non-session based computing system for greater usability and productivity is provided. Methods for operating such system are also provided. A handheld multi-mode input device supporting the methods and the system to achieve the objects is also provided.

Abstract: An apparatus and method is provided for determining, using real-time data, whether a removal process has been effective in removing a conductive coating from a removal site on a substrate of an electric device. The method includes determination of conductivity between the removal site and the intact conductive coating which relates to the absence or presence of the conductive coating in the removal site. The presence of conductive coating in the removal site indicates incomplete removal and thus enables real time correction thereof.

Abstract: A solar panel utilizes at least one and, in one embodiment, three protective layers to eliminate the need for a metal frame. The protective layers may include one inorganic layer and two polymer layers, which are cured onto an underside of the panel. In one embodiment, the protective layers are cured over lateral edges of certain of the layers of the solar panel, including for example the conductor layers, semiconductor junction, and reflector layer. The protective layers may extend to cover an exposed edge along an underside of panel's superstrate. In one embodiment, the lateral edge of the superstrate is contoured to resist damage from rough handling and/or exposure to the elements. A support platform may be provided, and the solar panel secured thereon by way of interposing an adhesive between an underside of the panel and the support platform.

Abstract: A tactical flashlight and/or laser mount structure has a chassis, two control buttons, an elastic means, a movable tenon and a mounting mortise. The chassis is fixed on the top of the tactical flashlight and/or laser for engaging the chassis with the gun separately. Each of the control buttons includes a pressing portion and a lift portion, the two control buttons are outward- and inward-movably disposed on the chassis, the elastic means is disposed between the two control buttons, a movable tenon is upward and downward movably disposed on the chassis and formed with two oblique notches, the lift portion of two control buttons joint to the oblique notches, and the mounting mortise is fixed on the gun.

Abstract: A tactical flashlight and/or laser mount structure has a chassis, two control buttons, an elastic means, a movable tenon and a mounting mortise. The chassis is fixed on the top of the tactical flashlight and/or laser for engaging the chassis with the gun separately. Each of the control buttons includes a pressing portion and a lift portion, the two control buttons are outward- and inward-movably disposed on the chassis, the elastic means is disposed between the two control buttons, a movable tenon is upward and downward movably disposed on the chassis and formed with two oblique notches, the lift portion of two control buttons joint to the oblique notches, and the mounting mortise is fixed on the gun.

Abstract: An upper cover plate for an air-tight chamber and a tool for removing the upper cover plate from the chamber are introduced. The upper cover plate integrates a chamber body to form the air-tight chamber, in which the chamber body further includes a top surface for air-tightly matching with a bottom surface of the upper cover plate. The upper cover plate further includes a plurality of thread holes engageable respectively with a plurality of the tools. The present invention is characterized on that at least one of the thread holes is formed as a through thread hole connecting to the bottom surface, and that the respective tool for engaging with the through thread hole includes a portion for penetrating the through thread hole and going beyond the bottom surface.