Patents by Inventor Philip LoGrasso

Philip LoGrasso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS AS JNK KINASE INHIBITORS
    Publication number: 20160304466
    Abstract: The present invention is directed to modulators, such as inhibitors, of JNK isoform 2 (JNK2) or isoform 3 (JNK3) comprising compounds of formula (I) or formula (II) as described herein. Compounds of the invention can be used for treatment of a medical disorder in a patient wherein modulation of JNK3 is medically indicated, such as when the disorder is Parkinson disease (PD) Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), myocardial infarction (MI), glaucoma, obesity, diabetes, cancer, rheumatoid arthritis, fibrotic disease, pulmonary fibrosis, kidney disease, liver inflammation, Crohns disease, hearing loss, Prader Willi syndrome, or a condition where modification of feeding behavior is medically indicated.
    Type: Application
    Filed: December 3, 2014
    Publication date: October 20, 2016
    Inventors: Yangbo Feng, Philip Lograsso, Ke Zheng, Chul Min Park
  • SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS
    Publication number: 20150232429
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Application
    Filed: April 27, 2015
    Publication date: August 20, 2015
    Inventors: Theodore Mark Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael Darin Cameron, Derek R. Duckett
  • Substituted pyrimidinyl-amines as protein kinase inhibitors
    Patent number: 9018205
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: April 28, 2015
    Assignee: The Scripps Research Institute
    Inventors: Theodore Mark Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael Darin Cameron, Derek R. Duckett
  • Substituted pyrimidinyl-amines as protein kinase inhibitors
    Patent number: 8530480
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: September 10, 2013
    Assignee: The Scripps Research Institute
    Inventors: Theodore Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael Darin Cameron, Derek R. Duckett
  • SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS
    Publication number: 20130231336
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Application
    Filed: February 13, 2013
    Publication date: September 5, 2013
    Applicant: The Scripps Research Institute
    Inventors: Theodore Mark Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael Darin Cameron, Derek R. Duckett
  • BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS
    Publication number: 20110150833
    Abstract: Compounds useful as Rho kinase inhibitors of formula (1) wherein the variables are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 23, 2011
    Applicant: The Scripps Research Institute
    Inventors: Yangbo Feng, Philip LoGrasso, Thomas Bannister, Thomas Schroeter, Yen Ting Chen, Yan Yin, Hampton Sessions, Michael P. Smolinski, Lei Yao, Bo Wang, Bozena Frackowiak-Wojtasek
  • BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS
    Publication number: 20110052562
    Abstract: Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R1, R2 and Ar1 are as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Application
    Filed: December 18, 2008
    Publication date: March 3, 2011
    Applicant: The Scripps Research Institute
    Inventors: Yangbo Feng, Philip LoGrasso, Thomas Bannister, Thomas Schroeter, Hampton Sessions, Lei Yao, Bo Wang, Michael P. Smolinski, Yen Ting Chen, Yan Yin, Bozena Frackowiak-Wojtasek, Sarwat Chowdhury
  • ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS
    Publication number: 20110038835
    Abstract: Compounds useful as Rho kinase inhibitors of formula (I): wherein variable are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.
    Type: Application
    Filed: December 18, 2008
    Publication date: February 17, 2011
    Applicant: The Scripps Research Institute
    Inventors: Yangbo Feng, Philip LoGrasso, Thomas Bannister, Thomas Schroeter, Xingang Fang, Yen ting Chen, Yan Yin, Michael P. Smolinski, Lei Yao, Bo Wang, Hampton Sessions
  • SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS
    Publication number: 20100298312
    Abstract: The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
    Type: Application
    Filed: September 3, 2008
    Publication date: November 25, 2010
    Applicant: The Scripps Research Institute
    Inventors: Theodore M. Kamenecka, Rong Jiang, Xinyi Song, Philip LoGrasso, Michael D. Cameron, Derek R. Duckett
  • Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as JNK-inhibitors
    Publication number: 20020032183
    Abstract: A method of promoting neuronal survival and helping prevent neuronal death administers (di-substituted-phenyl) pyrimidinyl imidazole derivative compounds represented by 1
    Type: Application
    Filed: September 17, 2001
    Publication date: March 14, 2002
    Inventors: Philip LoGrasso, JeanMarie Lisnock-Geissler, Steven Xanthoudakis, John Tam, Sarah J. Harper, James G. Bilsland, Lisa Young