Patents by Inventor Philip Low

Philip Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250082240
    Abstract: The present disclosure relates to methods and system for acquiring and analyzing biosignals or physiological signals of a person sitting in a vehicle and predicting (in real-time) time-varying attention, engagement level or alertness level using the biosignals. The biosignals may be acquired using one or more clusters of electrodes together with a wearable user device or from a sensing device that is embedded in the seat of the vehicle. In some embodiments, the biosignals may be utilized to predict restedness level of the subject, to monitor or predict physiological state of the subject, to detect a distress situation and to adapt a vehicle control accordingly. In some other embodiments, the biosignals can be transformed into communication, for example, speech signals or instructions for the vehicle. One or more actions may be triggered based on the analysis of the biosignals including engaging the person, generating alerts, or adapting the vehicle control.
    Type: Application
    Filed: September 9, 2024
    Publication date: March 13, 2025
    Applicant: NEUROVIGIL, INC.
    Inventor: Philip Low
  • Publication number: 20250083680
    Abstract: The present disclosure relates to methods and system for acquiring and analyzing biosignals or physiological signals of a person sitting in a vehicle and predicting (in real-time) time-varying attention, engagement level or alertness level using the biosignals. The biosignals may be acquired using one or more clusters of electrodes together with a wearable user device or from a sensing device that is embedded in the seat of the vehicle. In some embodiments, the biosignals may be utilized to predict restedness level of the subject, to monitor or predict physiological state of the subject, to detect a distress situation and to adapt a vehicle control accordingly. In some other embodiments, the biosignals can be transformed into communication, for example, speech signals or instructions for the vehicle. One or more actions may be triggered based on the analysis of the biosignals including engaging the person, generating alerts, or adapting the vehicle control.
    Type: Application
    Filed: September 9, 2024
    Publication date: March 13, 2025
    Inventor: Philip Low
  • Publication number: 20240335570
    Abstract: A conjugate of formula (I) FRTL-BBMecL-AA or (II) FRTL-Alb-BBMecL-AA, wherein FRTL is a folate receptor-targeting ligand, BBMecL is a brush border membrane (BBM) enzyme-cleavable linker, Alb is an albumin-binder moiety, and AA is an active agent; composition comprising same; and method of imaging and/or treating a tumor.
    Type: Application
    Filed: May 13, 2022
    Publication date: October 10, 2024
    Inventors: Philip LOW, Madduri SRINIVASARAO, Spencer LINDEMAN, Spencer GARDEEN
  • Publication number: 20240333813
    Abstract: Methods, systems, and computer programs are presented for lowering network latency for cloud-based services. Service-delivery edge locations allow customers to improve communication-providers public and private network connectivity for improved performance. One method includes operations for performing, by an edge server, a handshake to establish a communication session between a client and a main server, and for exchanging data between the client and the main server via the edge server. The handshake includes exchanging, by the edge server, communication initiation messages with the client, and validating, by the edge server, authentication credentials for the communication session based on the communication initiation messages.
    Type: Application
    Filed: June 11, 2024
    Publication date: October 3, 2024
    Inventors: Alexander Philip Lowe, Madeleine Genevieve Muscari, Robert Charles Hagemann, III, Christer Jan Erik Fahlgren, Jeremy Andrew McEntire, Erik A. Jansson, Humberto Reyes, Evan Kyle Fossier, Jingming Niu
  • Publication number: 20240285776
    Abstract: A conjugate of formula EVTsmL-L-AMRL, wherein EVTsmL is an enveloped virus-targeting, small molecule ligand, AMRL is an activated macrophage-recruiting ligand, and L is a linker that is covalently bound to EVTsmL and AMRL; a composition comprising the same; and a method of using the conjugate or composition to treat (therapeutically or prophylactically) a viral infection.
    Type: Application
    Filed: May 13, 2022
    Publication date: August 29, 2024
    Inventors: Philip LOW, Imrul SHAHRIAR
  • Patent number: 12041145
    Abstract: Methods, systems, and computer programs are presented for lowering network latency for cloud-based services. Service-delivery edge locations allow customers to improve communication-providers public and private network connectivity for improved performance. One method includes operations for performing, by an edge server, a handshake to establish a communication session between a client and a main server, and for exchanging data between the client and the main server via the edge server. The handshake includes exchanging, by the edge server, communication initiation messages with the client, and validating, by the edge server, authentication credentials for the communication session based on the communication initiation messages.
    Type: Grant
    Filed: February 2, 2023
    Date of Patent: July 16, 2024
    Assignee: Twilio Inc.
    Inventors: Alexander Philip Lowe, Madeleine Genevieve Muscari, Robert Charles Hagemann, III, Christer Jan Erik Fahlgren, Jeremy Andrew McEntire, Erik A. Jansson, Humberto Reyes, Evan Kyle Fossier, Jingming Niu
  • Publication number: 20240210386
    Abstract: Human leukocyte antigen (HLA) coated magnetic bead compositions, panels and methods of use thereof. A method of isolating HLA-specific antibodies including: contacting the composition of the disclosure with a liquid sample to specifically bind antibodies present in the liquid sample to HLA immobilized on magnetic beads; separating magnetic beads having antibodies bound to HLA of the magnetic beads from the liquid sample; and isolating the bound antibodies.
    Type: Application
    Filed: December 12, 2023
    Publication date: June 27, 2024
    Applicant: One Lambda, Inc.
    Inventors: Rui Pei, Quansheng Zhu, Tri Vu, David Philip Lowe
  • Publication number: 20240058478
    Abstract: A conjugate comprising a ligand that targets a folate receptor linked to an acrolein scavenger drug; a composition comprising same; a method of using the conjugate or the composition to scavenge acrolein, alone or in further combination with other reactive aldehyde species, in a subject with neurotrauma; and a method of delivering an acrolein scavenger or an imaging agent to the central nervous system (CNS) of a patient with inflammation in the CNS.
    Type: Application
    Filed: January 6, 2022
    Publication date: February 22, 2024
    Inventors: Spencer S. GARDEEN, Seth HERR, Philip LOW, Riyi SHI
  • Publication number: 20230346285
    Abstract: The present disclosure provides a device with electrodes configured to record electrical activity that are confined to a restricted area, using recorded biological electrical signals to control cursor position in a speech-assistance interface, and using recorded biological signals to detect arousals during sleep.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Inventor: Philip LOW
  • Patent number: 11690557
    Abstract: Determining low power frequency range information from spectral data. Raw signal data can be adjusted to increase dynamic range for power within low power frequency ranges as compared to higher-power frequency ranges to determine adjusted source data valuable for acquiring low power frequency range information. Low power frequency range information can be used in the analysis of a variety of raw signal data. For example, low power frequency range information within electroencephalography data for a subject from a period of sleep can be used to determine sleep states. Similarly, automated full-frequency spectral electroencephalography signal analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, and determining the effect of medication on sleep states.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: July 4, 2023
    Assignee: The Salk Institute For Biological Studies Intellectual Property And Technology Transfer
    Inventor: Philip Low
  • Patent number: 11672459
    Abstract: The present disclosure provides a device with electrodes configured to record electrical activity that are confined to a restricted area, using recorded biological electrical signals to control cursor position in a speech-assistance interface, and using recorded biological signals to detect arousals during sleep.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: June 13, 2023
    Assignee: NEUROVIGIL, INC.
    Inventor: Philip Low
  • Publication number: 20230179678
    Abstract: Methods, systems, and computer programs are presented for lowering network latency for cloud-based services. Service-delivery edge locations allow customers to improve communication-providers public and private network connectivity for improved performance. One method includes operations for performing, by an edge server, a handshake to establish a communication session between a client and a main server, and for exchanging data between the client and the main server via the edge server. The handshake includes exchanging, by the edge server, communication initiation messages with the client, and validating, by the edge server, authentication credentials for the communication session based on the communication initiation messages.
    Type: Application
    Filed: February 2, 2023
    Publication date: June 8, 2023
    Inventors: Alexander Philip Lowe, Madeleine Genevieve Muscari, Robert Charles Hagemann, III, Christer Jan Erik Fahlgren, Jeremy Andrew McEntire, Erik A. Jansson, Humberto Reyes, Evan Kyle Fossier, Jingming Niu
  • Patent number: 11601519
    Abstract: Methods, systems, and computer programs are presented for lowering network latency for cloud-based services. Service-delivery edge locations allow customers to improve communication-providers public and private network connectivity for improved performance. One method includes operations for performing, by an edge server, a handshake to establish a communication session between a client and a main server, and for exchanging data between the client and the main server via the edge server. The handshake includes exchanging, by the edge server, communication initiation messages with the client, and validating, by the edge server, authentication credentials for the communication session based on the communication initiation messages.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: March 7, 2023
    Assignee: Twilio Inc.
    Inventors: Alexander Philip Lowe, Madeleine Genevieve Muscari, Robert Charles Hagemann, III, Christer Jan Erik Fahlgren, Jeremy Andrew McEntire, Erik A. Jansson, Humberto Reyes, Evan Kyle Fossier, Jingming Niu
  • Publication number: 20210385292
    Abstract: Methods, systems, and computer programs are presented for lowering network latency for cloud-based services. Service-delivery edge locations allow customers to improve communication-providers public and private network connectivity for improved performance. One method includes operations for performing, by an edge server, a handshake to establish a communication session between a client and a main server, and for exchanging data between the client and the main server via the edge server. The handshake includes exchanging, by the edge server, communication initiation messages with the client, and validating, by the edge server, authentication credentials for the communication session based on the communication initiation messages.
    Type: Application
    Filed: August 12, 2020
    Publication date: December 9, 2021
    Inventors: Alexander Philip Lowe, Madeleine Genevieve Muscari, Robert Charles Hagemann, III, Christer Jan Erik Fahlgren, Jeremy Andrew McEntire, Erik A. Jansson, Humberto Reyes, Evan Kyle Fossier, Jingming Niu
  • Publication number: 20210212564
    Abstract: An assembly and system for collection and assessment of physiological data is provided. The assembly includes a physiological data acquisition module that may be used in combination with a head harness for the collection, recordation, storage and transmission of quality physiological data. The assembly integrates easy to use, self-applied electrodes in a user-friendly system resulting in less data artifacts than commonly seen in conventional methods and techniques for collecting physiological data. The assembly and system captures high-quality physiological data for display, storage, processing and analysis.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 15, 2021
    Inventors: Philip Low, Yu M. Chi, Siddharth Joshi, Christopher Uebelher, Yvon A. Dubois, Kevin Liu
  • Publication number: 20200167560
    Abstract: Determining low power frequency range information from spectral data. Raw signal data can be adjusted to increase dynamic range for power within low power frequency ranges as compared to higher-power frequency ranges to determine adjusted source data valuable for acquiring low power frequency range information. Low power frequency range information can be used in the analysis of a variety of raw signal data. For example, low power frequency range information within electroencephalography data for a subject from a period of sleep can be used to determine sleep states. Similarly, automated full-frequency spectral electroencephalography signal analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, and determining the effect of medication on sleep states.
    Type: Application
    Filed: July 31, 2019
    Publication date: May 28, 2020
    Inventor: Philip Low
  • Publication number: 20180201674
    Abstract: This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.
    Type: Application
    Filed: March 12, 2018
    Publication date: July 19, 2018
    Inventors: Philip Lowe, Hermann Gram, Thomas Jung, Timothy Wright, Trevor Mundel
  • Publication number: 20170218063
    Abstract: This invention relates to methods employing IL-1?-Ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1? ligand-IL-1 receptor interaction, IL-1? antibodies or IL-1 receptor antibodies, e.g. IL-1? binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1? binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1? ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
    Type: Application
    Filed: April 11, 2017
    Publication date: August 3, 2017
    Inventors: Philip Lowe, Hermann Gram, Thomas Jung, Timothy Wright, Trevor Mundel
  • Patent number: 9649377
    Abstract: This invention relates to methods employing IL-1?-ligand/IL-1 receptor disrupting compounds such as IL-1? antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of Familial Mediterranean Fever (FMF), in mammals, particularly humans.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: May 16, 2017
    Assignee: Novartis AG
    Inventors: Philip Lowe, Hermann Gram, Thomas Jung, Timothy Wright, Trevor Mundel
  • Publication number: 20160256067
    Abstract: The present disclosure provides a device with electrodes configured to record electrical activity that are confined to a restricted area, using recorded biological electrical signals to control cursor position in a speech-assistance interface, and using recorded biological signals to detect arousals during sleep.
    Type: Application
    Filed: October 14, 2014
    Publication date: September 8, 2016
    Applicant: Neurovigil, Inc.
    Inventor: Philip Low